Serological Patterns of Brucellosis, Leptospirosis and Q Fever in Bos indicus Cattle in Cameroon 英文参考文献.docVIP

SerologicalPatternsofBrucellosis,LeptospirosisandQ FeverinBosindicusCattleinCameroon FrancescaScolamacchia1,IanG.Handel1,EricM.Fe`vre2,KentonL.Morgan3,VincentN.Tanya4, BarendM.deC.Bronsvoort1* 1The Roslin Institute at the Royal (Dick) School of Veterinary Studies, University of Edinburgh, Roslin Biocentre, Roslin, Midlothian, United Kingdom, 2Institute of ImmunologyandInfectionResearch,SchoolofBiologicalSciences,UniversityofEdinburgh,Edinburgh,UnitedKingdom, 3DepartmentofVeterinaryClinicalSciences, UniversityofLiverpool,LeahurstVeterinaryTeachingHospital,Neston,Wirral,UnitedKingdom,4MinistryofScientificResearchandInnovation,Yaounde,Cameroon Abstract Brucellosis,leptospirosisandQfeverareimportantinfectionsoflivestockcausingarangeofclinicalconditionsincluding abortions and reduced fertility. In addition, they are all important zoonotic infections infecting those who work with livestock and those who consume livestock related products such as milk, producing non-specific symptoms including fever, that are often misdiagnosed and that can lead to severe chronic disease. This study used banked sera from the AdamawaRegionofCameroontoinvestigatetheseroprevalencesanddistributionsofseropositiveanimalsandherds.A classicalstatisticalandamulti-levelprevalencemodellingapproachwerecompared.Theunbiasedestimateswere*20%of herdswereseropositiveforBparedto*95%forLeptospiraspp.and*68%forQfever.Thewithin-herd seroprevalences were*16%, *35% and*39% respectively. There wasstatistical evidence ofclustering ofseropositive brucellosisandQfeverherds.Themodellingapproachhasthemajoradvantagethatestimatesofseroprevalencecanbe adjusted for the sensitivity and specificity of the diagnostic test used and the multi-level structure of the sampling. The studyfoundalowseroprevalenceofbrucellosisintheAdamawaRegioncomparedtoahighproportionofleptospirosisand Qfeverseropositiveherds.Thisrepresentsahighrisktothehumanpopulationaswellaspotentiallyhavingamajorimpact onanimalhealthandproductivityinther