Serum Phosphate Predicts Early Mortality in Adults Starting Antiretroviral Therapy in Lusaka, Zambia A Prospective Cohort Study 英文参考文献.docVIP
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SerumPhosphatePredictsEarlyMortalityinAdults
StartingAntiretroviralTherapyinLusaka,Zambia:A
ProspectiveCohortStudy
DouglasC.Heimburger1,2,3,6*,JohnR.Koethe1,3,ChristopherNyirenda1,5,ClaireBosire6,7,JanelleM.
Chiasera9,MeridithBlevins4,AndresJulianMunoz6,10,BryanE.Shepherd4,DaraPotter1,IsaacZulu1,5,
AngelaChisembele-Taylor1,BenjaminH.Chi1,8,JeffreyS.A.Stringer1,8,EdmondK.Kabagambe7
1CentreforInfectiousDiseaseResearchinZambia,Lusaka,Zambia,2InstituteforGlobalHealth,VanderbiltUniversity,Nashville,Tennessee,UnitedStatesofAmerica,
3DepartmentofMedicine,VanderbiltUniversity,Nashville,Tennessee,UnitedStatesofAmerica,4DepartmentofBiostatistics,VanderbiltUniversity,Nashville,Tennessee,
UnitedStatesofAmerica,5DepartmentofInternalMedicine,UniversityTeachingHospital,Lusaka,Zambia,6DepartmentofNutritionSciences,UniversityofAlabamaat
Birmingham,Birmingham,Alabama,UnitedStatesofAmerica,7DepartmentofEpidemiology,UniversityofAlabamaatBirmingham,Birmingham,Alabama,UnitedStates
ofAmerica,8DepartmentofObstetricsandGynecology,UniversityofAlabamaatBirmingham,Birmingham,Alabama,UnitedStatesofAmerica,9DepartmentofClinical
LaboratorySciences,UniversityofAlabamaatBirmingham,Birmingham,Alabama,UnitedStatesofAmerica,10DepartmentofInternalMedicine,UniversityofMichigan,
AnnArbor,Michigan,UnitedStatesofAmerica
Abstract
Background:Patientsstartingantiretroviraltherapy(ART)foracquiredimmunodeficiencysyndrome(AIDS)insub-Saharan
Africahavehighratesofmortalityintheinitialweeksoftreatment.Weassessedtheassociationofserumphosphatewith
earlymortalityamongHIV-infectedadultswithseveremalnutritionand/oradvancedimmunosuppression.
Methodology/PrincipalFindings:Anobservationalcohortof142HIV-infectedadultsinitiatingARTinLusaka,Zambiawith
+
bodymassindex(BMI),16kg/m2orCD4 lymphocytecount,50cells/mL,orboth,wasfollowedprospectivelyduringthe
first12weeksofART.Detailedhealthanddietaryintakehistory,reviewofsystems,physicalexamination,serummetabolic
panelincludingphosphate,andserumferritinandhigh-sensitivityC-reacti
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