Sesterterpenes and a New Sterol from the Marine Sponge Phyllospongia foliascens 英文参考文献.docVIP

Molecules 2010, 15, 834-841; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Sesterterpenes and a New Sterol from the Marine Sponge Phyllospongia foliascens Hong-Jun Zhang 1,2,3, Yang-Hua Yi 2, Fan Yang 1, Wan-Sheng Chen 1 and Hou-Wen Lin 1,* 1 Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, 415 Fengyang Road, Shanghai 200003, China; E-Mails: chinabludo@126.com (H.-J.Z.); bill1985@126.com (F.Y.); chenwansheng@21 (W.-S.C.) 2 Research Center for Marine Drugs, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, China; E-Mail: yiyanghua@ (Y.-H.Y.) 3 Hospital of PLA Troops 95746, 22 Jichang Road, Qionglai 611531, China * Author to whom correspondence should be addressed; E-Mail: franklin67@126.com; Tel./Fax: +86-21 Received: 27 December 2009; in revised form: 19 January 2010 / Accepted: 21 January 2010 / Published: 5 February 2010 Abstract: A new scalarane sesterterpene, phyllofolactone M (1), and a new sterol, (24E)- 5α,6α-epoxystigmasta-7,24(28)-dien-3β-ol (3), together with a known sesterterpene, phyllofolactone B (2), were isolated from the South China Sea sponge Phyllospongia foliascens. Their structures were elucidated by spectroscopic analysis and comparison with known compounds. In addition, previous NMR data assignments for the known sesterterpene phyllofolactone B (2) were revised. Keywords: sesterterpene; sterol; marine sponge; Phyllospongia foliascens 1. Introduction Scalarane sesterterpenes are typical bioactive secondary metabolites of marine sponges of the genus Phyllospongia [1,2]. The sponge P. foliascens was known to possess novel sesterterpenes with cytotoxic, antimicrobial, anti-inflammatory and anti-HIV activities, such as foliaspongin [3,4], phyllofoliaspongin [5], phyllactones [6], phyllofenones [7], and phyllofola