Severe reperfusion lung injury after double lung transplantation 英文参考文献.docVIP

Critical Care June 2002 Vol 6 No 3 Della Rocca et al. Research Severe reperfusion lung injury after double lung transplantation Giorgio Della Rocca1, Federico Pierconti2, Maria Gabriella Costa2, Cecilia Coccia2, Livia Pompei2, Monica Rocco1, Federico Venuta3 and Paolo Pietropaoli4 1Associate Professor, Istituto di Anestesiologia e Rianimazione, University of Rome ‘La Sapienza’, Rome, Italy 2Assistant, Istituto di Anestesiologia e Rianimazione, University of Rome ‘La Sapienza’, Rome, Italy 3Associate Professor, Cattedra di Chirurgia Toracica, University of Rome ‘La Sapienza’, Rome, Italy 4Director of Department, Istituto di Anestesiologia e Rianimazione, University of Rome ‘La Sapienza’, Rome, Italy Correspondence: Giorgio Della Rocca, giorgio.dellarocca@uniroma1.it Received: 15 November 2001 Revisions requested: 14 January 2002 Revisions received: 21 February 2002 Accepted: 7 March 2002 Critical Care 2002, 6:240-244 This article is online at /content/6/3/240 ? 2002 Della Rocca et al., licensee BioMed Central Ltd Published: 1 May 2002 (Print ISSN 1364-8535; Online ISSN 1466-609X) Abstract Aim: To demonstrate the effects of combined inhaled nitric oxide and surfactant replacement as treatment for acute respiratory distress syndrome. This treatment has not previously been documented for reperfusion injury after double lung transplantation. Method: A 24-year-old female with cystic fibrosis underwent double lung transplantation. During implantation of the second lung a marked increase in pulmonary artery pressure associated with systemic hypotension, hypoxemia and low cardiac output were observed. Notwithstanding the patient received support from cardiovascular drugs and pulmonary vasodilators cardiopulmonary by-pass was necessary. In the intensive care unit the patient received the same drug support, inhaled nitric oxide and two bronchoscopic applications of bovine surfactant. Results: A rapid improvement in PaO /FiO within