Seventy-Five Trials and Eleven Systematic Reviews a Day How Will We Ever Keep Up 英文参考文献.docVIP

PolicyForum Seventy-FiveTrialsandElevenSystematicReviewsaDay: HowWillWeEverKeepUp? HildaBastian1*,PaulGlasziou2,IainChalmers3 1GermanInstituteforQualityandEfficiencyinHealthCare(IQWiG),Cologne,Germany,2CentreforResearchinEvidence-BasedPractice,FacultyofHealthSciences,Bond University,GoldCoast,Australia,3JamesLindLibrary,JamesLindInitiative,Oxford,UnitedKingdom Thirty years ago, and a quarter of a century after randomised trials had be- come widely accepted, Archie Cochrane SummaryPoints N When Archie Cochrane reproached the medical profession for not having reproachedthemedicalprofessionfornot having managed to organise a ‘‘critical summary, by speciality or subspeciality, adapted periodically, of all relevant ran- domised controlled trials’’ [1]. Thirty years after Cochrane’s reproach we feel itistimelytoconsidertheextenttowhich healthprofessionals,thepublicandpolicy- makers could now use ‘‘critical summa- ries’’oftrialsfortheirdecision-making. criticalsummariesofallrandomisedcontrolledtrials,about14reportsoftrials were being published per day. There are now 75 trials, and 11 systematic reviewsoftrials,perdayandaplateauingrowthhasnotyetbeenreached. N Althoughtrials,reviews,andhealthtechnologyassessmentshaveundoubtedly hadmajorimpacts,thestapleofmedicalliteraturesynthesisremainsthenon- systematic narrative review. Only a small minority of trial reports are being analysed in up-to-date systematic reviews. Given the constraints, Archie Cochrane’svisionwillnotbeachievedwithoutsomeseriouschangesincourse. N Tomeettheneedsofpatients,clinicians,andpolicymakers,unnecessarytrials needtobereduced,andsystematicreviewsneedtobeprioritised.Streamlining and innovation in methods of systematic reviewing are necessary to enable valid answers to be found for most patient questions. Finally, clinicians and patientsrequireopenaccesstotheseimportantresources. TheLandscape Keeping up with information in health care has never been easy. Even in 1753, whenJames Lindpublishedhislandmark