Sex- and Age-Related Differences in Morbidity Rates of 2009 Pandemic Influenza A H1N1 Virus of Swine Origin in Japan 英文参考文献.docVIP

Sex-andAge-RelatedDifferencesinMorbidityRatesof 2009PandemicInfluenzaAH1N1VirusofSwineOrigin inJapan NobuokiEshima1.,OsamuTokumaru2*.,ShoheiHara3,KiraBacal4,SeigoKorematsu5,MinoruTabata6, ShigeruKarukaya7,YoshinoriYasui8,NobuhikoOkabe8,ToyojiroMatsuishi7 1DepartmentofBiostatistics,OitaUniversityFacultyofMedicine,YufuCity,Oita,Japan,2DepartmentofNeurophysiology,OitaUniversityFacultyofMedicine,YufuCity, Oita,Japan,3TheYomiuriShimbunOsaka(Newspaper),Osaka,Japan,4MedicalProgrammeDirectorate,FacultyofMedicalandHealthSciences,UniversityofAuckland, Auckland,NewZealand,5DepartmentofPediatrics,OitaUniversityFacultyofMedicine,YufuCity,Oita,Japan,6DepartmentofMathematicalSciences,GraduateSchool ofEngineering,OsakaPrefectureUniversity,SakaiCity,Osaka,Japan,7DepartmentofPediatrics,KurumeUniversitySchoolofMedicine,KurumeUniversity,KurumeCity, Fukuoka,Japan,8InfectiousDiseaseSurveillanceCenter,NationalInstituteofInfectiousDiseases,Tokyo,Japan Abstract Background: The objective of the present study was to determine whether the morbidity rates of the 2009 pandemic influenzaAH1N1virus(pdmH1N1)variedbyageand/orsex. Methods and Findings: Retrospective analysis of 2,024,367 cases of pdmH1N1 was performed using the national surveillancedatafrominfluenzasentinelpointsinJapan.Themale-to-femalemorbidityratios(M/Fratios)innineteenage groupswereestimatedastheprimaryoutcome.TheM/FratiosforpdmH1N1influenzawere:.1inagegroups,20years and$80years(p,0.001);,1inagegroups20–79years(p,0.001).Thisdatasuggeststhatmales,20yearsofagemaybe more likely to suffer from pdmH1N1 influenza than females in the same age categories. When the infection pattern for pdmH1N1wascomparedwiththatofseasonalinfluenzaoutbreaksbetween2000and2008,theM/FratioforpdmH1N1 influenza was higher in ages 3–29 years and lower in ages 40–79 years. Because the present study was based on the nationalsurveillance,itwasimpossibletoestimatethemorbidityratefortheJapanesepopulation.Itisalsolikelythatthe datadidnotcaptureasymptomaticormildinf