Sexually dimorphic effect of aging on skeletal muscle protein synthesis 英文参考文献.docVIP

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Sexually dimorphic effect of aging on skeletal muscle protein synthesis 英文参考文献.doc

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Sexually dimorphic effect of aging on skeletal muscle protein synthesis 英文参考文献

Smithetal.BiologyofSexDifferences2012,3:11 /content/3/1/11 RESEARCH OpenAccess Sexuallydimorphiceffectofagingonskeletal muscleproteinsynthesis GordonISmith,DominicNReeds,AngelaMHall,KariTChambers,BrianNFinckandBettinaMittendorfer* Abstract Background:Althoughthereappeartobenodifferencesinmuscleproteinturnoverinyoungandmiddleaged menandwomen,wehavereportedsignificantdifferencesintherateofmuscleproteinsynthesisbetweenolder adultmenandwomen.Thissuggeststhatagingmayaffectmuscleproteinturnoverdifferentlyinmenand women. Methods:Wemeasuredtheskeletalmuscleproteinfractionalsynthesisrate(FSR)byusingstableisotope-labeled tracermethodsduringbasalpostabsorptiveconditionsandduringahyperaminoacidemic-hyperinsulinemic- euglycemicclampineightyoungmen(25–45y),tenyoungwomen(25–45y),tenoldmen(65–85y)andtenold women(65–85y). Results:The basal muscle protein FSR was not different in young and old men (0.040±0.004 and 0.043±0.005%áh-1, respectively) and combined insulin, glucose and amino acid infusion significantly increased the muscle protein FSR both in young (to 0.063±0.006%áh-1) and old (to 0.051±0.008%áh-1) men but the increase (0.023±0.004 vs. -1 0.009±0.004%áh , respectively) was ~60% less in the old men (P=0.03). In contrast, the basal muscle protein FSR -1 was ~30% greater in old than young women (0.060±0.003 vs. 0.046±0.004%áh , respectively; P0.05) and combined insulin, glucose and amino acid infusion significantly increased the muscle protein FSR in young (P0.01) but not in old women (P=0.10) so that the FSR was not different between young and old women during the clamp (0.074±0.006%áh-1 vs. 0.072±0.006%áh-1 , respectively). Conclusions: There is sexual dimorphism in the age-related changes in muscle protein synthesis and thus the metabolic processes responsible for the age-related decline in muscle mass. Keywords: Muscle protein turnover, Aging, Sarcopenia, Amino acid Background responsestonutritionalstimuli[11]andresistanceexer- Understandinghowagingaffectsmuscleproteinmet