Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium 英文参考文献.docVIP

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Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium 英文参考文献.doc

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Sfrp Controls Apicobasal Polarity and Oriented Cell Division in Developing Gut Epithelium 英文参考文献

SfrpControlsApicobasalPolarityandOrientedCell DivisioninDevelopingGutEpithelium MakotoMatsuyama1¤,ShinichiAizawa1,AkihikoShimono2* 1Vertebrate BodyPlan,CenterforDevelopmentalBiology,RIKENKobe,Minatojima-Minami,Chuou-ku,Kobe,Japan,2CancerScienceInstituteofSingapore,National UniversityofSingapore,CentreforLifeSciences#02-07,Singapore,Singapore Abstract Epithelialtubularmorphogenesisleadingtoalterationoforganshapehasimportantphysiologicalconsequences.However, littleisknownregardingthemechanismsthatgovernepithelialtubemorphogenesis.Here,weshowthatinactivationof Sfrp1andSfrp2leadstoreductioninfore-stomachlengthinmouseembryos,whichisenhancedinthepresenceoftheSfrp5 mutation.Inthemono-celllayeroffore-stomachepithelium,celldivisionisnormallyorientedalongthecephalocaudalaxis; incontrast,orientationdivergesintheSfrps-deficientfore-stomach.CellgrowthandapoptosisarenotaffectedintheSfrps- deficient fore-stomach epithelium. Similarly, cell division orientation in fore-stomach epithelium diverges as a result of inactivation of either Stbm/Vangl2, an Fz/PCP component, or Wnt5a. These observations indicate that the oriented cell division, which is controlled by the Fz/PCP pathway, is one of essential components in fore-stomach morphogenesis. Additionally, the small intestine epithelium of Sfrps compound mutants fails to maintain proper apicobasal polarity; the defectwasalsoobservedinWnt5a-inactivatedsmallintestine.Inrelationtothesefindings,Sfrp1physicallyinteractswith Wnt5aandinhibitsWnt5asignaling.WeproposethatSfrpregulationofWnt5asignalingcontrolsorientedcelldivisionand apicobasalpolarityintheepitheliumofdevelopinggut. Citation:MatsuyamaM,AizawaS,ShimonoA(2009)SfrpControlsApicobasalPolarityandOrientedCellDivisioninDevelopingGutEpithelium.PLoSGenet5(3): e1000427.doi:10.1371/journal.pgen.1000427 Editor:AnthonyWynshaw-Boris,UniversityofCaliforniaSanFrancisco,UnitedStatesofAmerica ReceivedAugust8,2008;AcceptedFebruary17,2009;PublishedMarch20,2009 Copyright:?2009Matsuyamaetal.Thisisan