Short-term administration of growth hormone (GH) lowers blood pressure by activating eNOSnitric oxide (NO)-pathway in male hypophysectomized (Hx) rats 英文参考文献.docVIP

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Short-term administration of growth hormone (GH) lowers blood pressure by activating eNOSnitric oxide (NO)-pathway in male hypophysectomized (Hx) rats 英文参考文献.doc

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Short-term administration of growth hormone (GH) lowers blood pressure by activating eNOSnitric oxide (NO)-pathway in male hypophysectomized (Hx) rats 英文参考文献

BMC Physiology BioMedCentral Research article Open Access Short-term administration of growth hormone (GH) lowers blood pressure by activating eNOS/nitric oxide (NO)-pathway in male hypophysectomized (Hx) rats Henrik C Nystr?m1, Natalia Klintland2, Kenneth Caidahl2, G?ran Bergstr?m1,2 and Anna Wickman*1 Address: 1Department of Physiology, Institute of Physiology Pharmacology, The Sahlgrenska Academy, G?teborg University, P.O. Box 432, SE- 405 30 G?teborg, Sweden and 2Department of Clinical Physiology, Sahlgrenska University Hospital/SU, SE-413 45 G?teborg, Sweden Email: Henrik C Nystr?m - henrik.nystrom@fysiologi.gu.se; Natalia Klintland - nkharitonova@; Kenneth Caidahl - kencai@ki.se; G?ran Bergstr?m - goran.bergstrom@hjl.gu.se; Anna Wickman* - anna.wickman@fysiologi.gu.se * Corresponding author Published: 07 November 2005 Received: 18 May 2005 Accepted: 07 November 2005 BMC Physiology 2005, 5:17 doi:10.1186/147 2-67 93-5-17 This article is available from: /147 2-67 93/5/17 ? 2005 Nystr?m et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The aim of the study was to evaluate the acute and continuous (up to 14 days of treatment) effect of growth hormone (GH) on blood pressure (BP) regulation and to investigate the interplay between GH, nitric oxide (NO) and BP. In un-supplemented and GH supplemented hypophysectomized (Hx) male rats as well as intact rats, continuous resting mean arterial blood pressure (MAP) was measured using telemetry. Baroreceptor activity and the influences of NO on BP control were assessed during telemetric measurement. Furthermore, basal plasma and urine nitrate levels and aortic endothelial nitric oxide synthase (eNOS) expression were