Shining light on lupus and UV 英文参考文献.docVIP

Available online /content/9/1/101 Editorial Shining light on lupus and UV Melanie K Kuechle1 and Keith B Elkon2 1Division of Dermatology, University of Washington School of Medicine, NE Pacific Street, Seattle, WA 98195, USA 2Division of Rheumatology, University of Washington School of Medicine, NE Pacific Street, Seattle, WA 98195, USA Corresponding author: Keith B Elkon, elkon@ Published: 18 January 2007 Arthritis Research Therapy 2007, 9:101 (doi:10.1186/ar2100) This article is online at /content/9/1/101 ? 2007 BioMed Central Ltd See related research by Reefman et al., /content/8/6/R156 Abstract Lupus photosensitivity could be caused by an aberrant response of keratinocytes to UV injury, defective clearance of apoptotic cells or an abnormal immune response to these cells. Reefman and colleagues [7] previously reported that, 24 hours after UVB radiation, there were no differences in the numbers of epidermal apoptotic cells between lupus patients People exposed to sunlight can develop erythema, DNA damage, photoimmunosupression. Extended exposure of normal and epidermis to sunlight will induce dysmorphic keratinocytes with pyknotic nuclei scattered throughout the spinous layer. These ‘sunburn cells’ are apoptotic keratinocytes and are usually cleared within 48 hours after sunburn. Patients with lupus erythematosus, however, whether it be the discoid, subacute cutaneous, systemic, or tumid form, develop new cutaneous lesions and can experience and controls, leading to the conclusion that lupus keratinocytes were not hypersensitive to UV light. However, our previous analysis of UV responses of keratinocytes in vitro did suggest increased sensitivity of lupus keratinocytes, as determined by translocation of lupus autoantigens to apoptotic blebs [8], and enhanced UVB induced death was also observed by others [9]. Further studies in this area are clearly