Shedding Light on the Elusive Role of Endothelial Cells in Cytomegalovirus Dissemination 英文参考文献.docVIP

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Shedding Light on the Elusive Role of Endothelial Cells in Cytomegalovirus Dissemination 英文参考文献.doc

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Shedding Light on the Elusive Role of Endothelial Cells in Cytomegalovirus Dissemination 英文参考文献

SheddingLightontheElusiveRoleofEndothelialCellsin CytomegalovirusDissemination TorstenSacher1.,JoachimAndrassy2.,AivarsKalnins2,LarsDo¨lken1,StefanJordan1,Ju¨rgenPodlech3, ZsoltRuzsics1,Karl-WalterJauch2,MatthiasJ.Reddehase3,UlrichH.Koszinowski1* 1MaxvonPettenkofer-Institute,LudwigMaximilians-University,Munich,Germany,2SurgeryDepartment,KlinikumGro?hadern,LudwigMaximilians-University,Munich, Germany,3InstituteforVirology,UniversityMedicalCenteroftheJohannesGutenberg-UniversityMainz,Mainz,Germany Abstract Cytomegalovirus (CMV) is frequently transmitted by solid organ transplantation and is associated with graft failure. By formingtheboundarybetweencirculationandorganparenchyma,endothelialcells(EC)aresuitedforbidirectionalvirus spreadfromandtothetransplant.WeappliedCre/loxP-mediatedgreen-fluorescence-taggingofEC-derivedmurineCMV (MCMV)toquantifytheroleofinfectedECintransplantation-associatedCMVdisseminationinthemousemodel.BothEC- and non-EC-derived virus originating from infected Tie2-cre+ heart and kidney transplants were readily transmitted to + MCMV-na?¨verecipientsbyprimaryviremia.Incontrast,whenaTie2-cre transplantwasinfectedbyprimaryviremiainan infected recipient, the recombined EC-derived virus poorly spread to recipient tissues. Similarly, in reverse direction, EC- + derivedvirusfrominfectedTie2-cre recipienttissuespoorlyspreadtothetransplant.Thesedatacontradictanyprivileged roleofECinCMVdisseminationandchallengeanindiscriminateapplicabilityoftheprimaryandsecondaryviremiaconcept ofvirusdissemination. Citation: Sacher T, Andrassy J, Kalnins A, Do¨lken L, Jordan S, et al. (2011) Shedding Light on the Elusive Role of Endothelial Cells in Cytomegalovirus Dissemination.PLoSPathog7(11):e1002366.doi:10.1371/journal.ppat.1002366 Editor:JayA.Nelson,OregonHealthandScienceUniversity,UnitedStatesofAmerica ReceivedMay24,2011;AcceptedSeptember22,2011;PublishedNovember17,2011 Copyright: ? 2011 Sacher et al. This is an open-access article distributed under the terms