Short-term effects of positive end-expiratory pressure on breathing pattern an interventional study in adult intensive care patients 英文参考文献.docVIP

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Short-term effects of positive end-expiratory pressure on breathing pattern an interventional study in adult intensive care patients 英文参考文献.doc

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Available online /content/9/4/R407 Research Open Access Vol 9 No 4 Short-term effects of positive end-expiratory pressure on breathing pattern: an interventional study in adult intensive care patients Christoph Haberthür1 and Josef Guttmann2 1Assistant Professor and head of Surgical Intensive Care Medicine, Department of Anaesthesia, Kantonsspital Luzern, Switzerland 2Professor in Biomedical Engineering, Section of Experimental Anaesthesiology, Department of Anaesthesia and Critical Care Medicine, University of Freiburg, Germany Corresponding author: Christoph Haberthür, christoph.haberthuer@ksl.ch Received: 13 Jan 2005 Revisions requested: 16 Feb 2005 Revisions received: 18 Apr 2005 Accepted: 11 May 2005 Published: 9 Jun 2005 Critical Care 2005, 9:R407-R415 (DOI 10.1186/cc3735) This article is online at: /content/9/4/R407 ? 2005 Haberthür and Guttmann; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Positive end-expiratory pressure (PEEP) is used in mechanically ventilated patients to increase pulmonary volume and improve gas exchange. However, in clinical practice and with respect to adult, ventilator-dependent patients, little is known about the short-term effects of PEEP on breathing patterns. either direction resulted in a change in rate of 0.4 breaths/min. The effects were exclusively due to changes in expiratory time. Effects began to manifest during the first breath and became fully established in the second breath for each PEEP level. Identical responses were found when PEEP levels were applied for 10 or 60 s. Post hoc analysis revealed a similar but stronger response in patients with impaired respiratory system Methods In 30 tracheally intubated, s