Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity 英文参考文献.docVIP

下载本文档

5
0
约3.9万字
约 9页
2017-05-13 发布于上海
举报
版权申诉

Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity 英文参考文献.doc

1、本文档共9页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Shortest-Path Network Analysis Is a Useful Approach toward Identifying Genetic Determinants of Longevity 英文参考文献

Shortest-PathNetworkAnalysisIsaUsefulApproach towardIdentifyingGeneticDeterminantsofLongevity J.R.Managbanag1,TarynnM.Witten1*,DanailBonchev1,2,LindsayA.Fox3,MitsuhiroTsuchiya3,BrianK. Kennedy3,MattKaeberlein4* 1Center for the Study of Biological Complexity, Virginia Commonwealth University, Richmond, Virginia, United States of America, 2Department of Mathematics and AppliedMathematics,VirginiaCommonwealthUniversity,Richmond,Virginia,UnitedStatesofAmerica,3DepartmentofBiochemistry,UniversityofWashington,Seattle, Washington,UnitedStatesofAmerica,4DepartmentofPathology,UniversityofWashington,Seattle,Washington,UnitedStatesofAmerica Abstract Background:Identificationofgenesthatmodulatelongevityisamajorfocusofaging-relatedresearchandanareaofintense publicinterest.Inadditiontofacilitatinganimprovedunderstandingofthebasicmechanismsofaging,suchgenesrepresent potentialtargetsfortherapeuticinterventioninmultipleage-associateddiseases,includingcancer,heartdisease,diabetes,and neurodegenerativedisorders.Todate,however,targetedeffortsatidentifyinglongevity-associatedgeneshavebeenlimitedby alackofpredictivepower,andusefulalgorithmsforcandidategene-identificationhavealsobeenlacking. Methodology/PrincipalFindings:Wehaveutilizedashortest-pathnetworkanalysistoidentifynovelgenesthatmodulate longevityinSaccharomycescerevisiae.Basedonasetofpreviouslyreportedgenesassociatedwithincreasedlifespan,we applied a shortest-path network algorithm to a pre-existing protein–protein interaction dataset in order to construct a shortest-pathlongevitynetwork.Tovalidatethisnetwork,thereplicativeagingpotentialof88single-genedeletionstrains correspondingtopredictedcomponentsoftheshortest-pathlongevitynetworkwasdetermined.Herewereportthatthe single-gene deletion strains identified by our shortest-path longevity analysis are significantly enriched for mutations conferringeitherincreasedordecreasedreplicativelifespan,relativetoarandomlyselectedsetof564single-genedeletion strainsortothecurrentdatasetavail