麦冬治疗妊娠期糖尿病胰岛素抵抗的作用及机制.docVIP

　　麦冬治疗妊娠期糖尿病胰岛素抵抗的作用及机制 作者：李瑞满，秦佳佳,裴兆辉 【摘要】 目的：观察麦冬 治疗 妊娠糖尿病胰岛素抵抗的作用， 研究 其作用机制. 方法 ：选妊娠10 d大鼠，建立妊娠糖尿病胰岛素抵抗动物模型，正常大鼠为对照组，随机将40只妊娠糖尿病胰岛素抵抗大鼠分为4组（n=10）：GDM组、GDM＋麦冬组、GDM＋罗格列酮和GDM＋罗格列酮+麦冬组. 观察用药前后血糖、胰岛素的变化，检测腹腔脂肪组织中TNFα与leptin的mRNA表达变化. 结果：与对照组比较，GDM组大鼠空腹及餐后血糖与胰岛素较正常对照组明显升高（Plt;0.05），TNFα与leptin的mRNA表达明显增加（Plt;0.05）；与GDM组比较，麦冬治疗组、罗格列酮治疗组、罗格列酮+麦冬治疗组大鼠空腹及餐后血糖均下降（Plt;0.05），TNFα与leptin的mRNA表达明显降低（Plt;0.05）；与麦冬治疗组比较，罗格列酮治疗组空腹及餐后血糖无明显变化（Pgt;0.05），TNFα与leptin的mRNA表达无明显变化（Pgt;0.05），罗格列酮+麦冬治疗组空腹及餐后血糖明显下降（Plt;0.01），TNFα与leptin的mRNA表达明显降低（Plt;0.05）；与罗格列酮组比较，罗格列酮+麦冬治疗组空腹及餐后血糖明显下降（Plt;0.01），TNFα与leptin的mRNA表达明显变化（Plt;0.05）. 结论：麦冬治疗妊娠期糖尿病疗效明显，能变胰岛素抵抗状态，其机制与TNFα与leptin的mRNA表达的变化有关. 【关键词】 中药;麦冬属；妊娠期糖尿病；胰岛素抵抗；肿瘤坏死因子α；瘦素 　　【Abstract】 AIM: To investigate the treatment effect of Chinese herb Maidong on gestational diabetes mellitus (GDM) and insulin resistance (IR) and to study its underlying mechanism. METHODS: GDM plicated by IR al rats served as a control group. Forty model rats ized into GDM group, GDM Maidong group, GDM rosiglitazone maleate group, GDM, Maidong rosiglitazone maleate group (n=10). Serum glucose and serum insulin ined after and before administration. The expressions of TNFα and leptin inal adipose tissues after and before administration. RESULTS: pared to controls, serum glucose and serum insulin glucose and serum insulin p; Maidong group, GDM rosiglitazone maleate group, GDM Maidong rosiglitazone maleate group. pared to GDM Maidong group, serum glucose and serum insulin remained unchanged （Pgt;0.05）and the expressions of TNFα and leptin aleate group, glucose, and serum insulin （Plt;0.01） and the expressions of TNFα and leptin p; rosiglitazone maleate group. pared to rosiglitazone maleate group, serum glucose and serum insulin p; rosiglitazone maleate group. CONCLUSION: Treatment effect of Chinese herb Maidong is good for GDM and can reverse IR. These actions are related to the changes of the contents of TNFα and leptin. 　　【Keyellitus (GDM); insu