Stem cell transplantation for type 1 diabetes mellitus 英文参考文献.docVIP

Diabetology Metabolic Syndrome BioMedCentral Review Open Access Stem cell transplantation for type 1 diabetes mellitus Júlio C Voltarelli* and Carlos Eduardo Barra Couri Address: Department of Clinical Medicine, Ribeir?o Preto School of Medicine, University of S?o Paulo, Brazil Email: Júlio C Voltarelli* - jcvoltar@fmrp.usp.br; Carlos Eduardo Barra Couri - ce.couri@.br * Corresponding author Published: 16 September 2009 Received: 7 April 2009 Accepted: 16 September 2009 Diabetology Metabolic Syndrome 2009, 1:4 doi:10.1186/1758-5996-1-4 This article is available from: /content/1/1/4 ? 2009 Voltarelli and Couri; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The use of stem cells to treat type 1 diabetes mellitus has been proposed for many years, both to downregulate the immune system and to provide β cell regeneration. Conclusion: High dose immunosuppression followed by autologous hematopoietic stem cell transplantation is able to induce complete remission (insulin independence) in most patients with early onset type 1 diabetes mellitus. Introduction ing importance in therapeutics. One of them is the endothelial precursor cells, capable of angiogenesis and they are widely used nowadays in regenerative therapy. Another type of SC is the mesenchymal stem cell, which has a powerful immunosuppressant capacity and is also capable to differentiate into several tissues. Therefore, these three types of stem cells, hematopoietic, endothelial and mesenchymal, have been used in therapy and may be applied to the treatment of diabetes[5]. Type 1 diabetes (T1DM) is an autoimmune disease through which the patients immune system loses the immuno