Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers 英文参考文献.docVIP

Pharmaceutics 2011, 3, 636-664; doi:10.3390/pharmaceutics3030636 OPEN ACCESS pharmaceutics ISSN 1999-4923 /journal/pharmaceutics Review Structural Versatility of Bicellar Systems and Their Possibilities as Colloidal Carriers Barbosa-Barros Lucyanna 1, Rodríguez Gelen 2, Cócera Merce 2, Rubio Laia 2, López-Iglesias Carmen 3, de la Maza Alfons 2 and López Olga 2,* 1 Departament de Fisicoquímica, Facultat de Farmàcia, Universitat de Barcelona, 08028 Barcelona, Spain 2 Departament de Tecnologia Química i de Tensioactius, Institut de Química Avan?ada de Catalunya (I.Q.A.C.), Consejo Superior de Investigaciones Científicas (C.S.I.C.), C/Jordi Girona 18-26, 08034 Barcelona, Spain 3 Centres Científics i Tecnològics, Universitat de Barcelona, Parc Científic de Barcelona, C/Josep Samitier 1-5, 08028 Barcelona, Spain * Author to whom correspondence should be addressed; E-Mail: oloesl@cid.csic.es; Tel.: 0034-93-4006163; Fax: 0034-93-2045904. Received: 3 June 2011; in revised form: 21 July 2011 / Accepted: 5 September 2011 / Published: 14 September 2011 Abstract: Bicellar systems are lipid nanostructures formed by long- and short-chained phospholipids dispersed in aqueous solution. The morphological transitions of bicellar aggregates due to temperature, composition and time variations have been revised in this work. To this end, two bicellar systems have been considered; one formed by dimyristoyl-phosphatidylcholine (DMPC) and dihexanoyl- phosphatidylcholine (DHPC) and another formed by dipalmitoyl-phosphatidylcholine (DPPC) and DHPC. The relationship between the magnetic alignment, the morphology of the aggregates and the phase transition temperature (Tm) of lipids is discussed. In general terms, the non-alignable samples present rounded objects at temperature below the Tm. Above this temperature, an increase of viscosity is followed by the formation of large elongated a