Sub-typing of renal cell tumours; contribution of ancillary techniques 英文参考文献.docVIP

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Sub-typing of renal cell tumours; contribution of ancillary techniques 英文参考文献.doc

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Sub-typing of renal cell tumours; contribution of ancillary techniques 英文参考文献

Diagnostic Pathology BioMedCentral Short report Open Access Sub-typing of renal cell tumours; contribution of ancillary techniques Dinesh Pradhan?1, Nandita Kakkar?1, Amanjit Bal?1, Shrawan Kumar Singh?2 and Kusum Joshi*1 Address: 1Department of Histopathology, Post Graduate Institute of Medical Sciences Research, (PGIMER), Chandigarh, India and 2Advanced Urology Centre, Post Graduate Institute of Medical Sciences Research, (PGIMER), Chandigarh, India Email: Dinesh Pradhan - dppgi4u@; Nandita Kakkar - nandita_kakkar@; Amanjit Bal - docaman5@; Shrawan Kumar Singh - pgimer@chd.nic.in; Kusum Joshi* - kus_joshi@ * Corresponding author ?Equal contributors Published: 28 June 2009 Received: 12 May 2009 Accepted: 28 June 2009 Diagnostic Pathology 2009, 4:21 doi:10.1186/1746-1596-4-21 This article is available from: /content/4/1/21 ? 2009 Pradhan et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: Adult renal epithelial neoplasms are a heterogeneous group with varying prognosis and outcome requiring sub-classification. Methods: Cases of renal cell carcinoma (RCC) in a 10 years period were analyzed with regard to the clinical features and histology. Sections were reviewed by four pathologists and the discordant cases were resolved with the help of Hales colloidal iron stain, vimentin, CK 7, and vinculin immunostains and electron microscopy. Results: Amongst the total of 278 cases, clear cell renal cell carcinoma was the commonest tumor with 74.8% cases, followed by papillary RCC 12.2%, chromophobe RCC 7.9%, oncocytoma 1.8%, and one case of collecting duct RCC. Eight cases were of sarcomatoid renal cell carcinoma. In 28/ 278 cases, diagnoses varied amongst the four pathologists and the