Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 1300.4 a microvascular perspective 英文参考文献.docVIP

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Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 1300.4 a microvascular perspective 英文参考文献.doc

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Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 1300.4 a microvascular perspective 英文参考文献

Available online /content/12/2/R54 Research Open Access Vol 12 No 2 Survival time in severe hemorrhagic shock after perioperative hemodilution is longer with PEG-conjugated human serum albumin than with HES 130/0.4: a microvascular perspective Judith Martini1, Pedro Cabrales2, Ananda K3, Seetharama A Acharya3, Marcos Intaglietta1 and Amy G Tsai1,2 1Department of Bioengineering, University of California, San Diego, Gilman Dr, La Jolla, California 92093, USA 2La Jolla Bioengineering Institute, Coast Blvd South, La Jolla, California 92037, USA 3Department of Hematology and Medicine, Albert Einstein College of Medicine, Morris Park Avenue, Bronx, New York 10461, USA Corresponding author: Amy G Tsai, agtsai@ Received: 25 Jan 2008 Revisions requested: 25 Feb 2008 Revisions received: 14 Mar 2008 Accepted: 18 Apr 2008 Published: 18 Apr 2008 Critical Care 2008, 12:R54 (doi:10.1186/cc6874) This article is online at: /content/12/2/R54 ? 2008 Martini et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Preoperative hemodilution is an established practice that is applied to reduce surgical blood loss. It has been proposed that polyethylene glycol (PEG) surface decorated proteins such as PEG-conjugated human serum albumin may be used as non-oxygen-carrying plasma expanders. The purpose of this study was to determine whether there is any difference in survival time after severe hemorrhagic shock following extreme hemodilution using a conventional hydroxyethyl starch (HES)- based plasma expander or PEG-albumin. Results The PEG-albumin group exhibited significantly greater survival rate than did the HES group, in which none of the animals survived the hemorrhage phase of the experime