T-helper cells as new players in ANCA-associated vasculitides 英文参考文献.docVIP

Abdulahad et al. Arthritis Research Therapy 2011,13:236 /content/13/4/236 REVIEW T-helper cells as new players in ANCA-associated vasculitides Wayel H Abdulahad*, Peter Lamprecht and Cees GM Kallenberg 1 2 1 ANCA in vivo bind to surface-expressed autoantigens (PR3 or MPO) on primed neutrophils, which enhances neutrophil degranulation and the release of toxic products that cause endothelial damage, ultimately leading to necrotizing vasculiti