原创力文档The epigenetic effects of butyrate potential therapeutic implications for clinical practice 英文参考文献.docVIP
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The epigenetic effects of butyrate potential therapeutic implications for clinical practice 英文参考文献
BerniCananietal.ClinicalEpigenetics2012,4:4
/content/4/1/4
REVIEW
OpenAccess
Theepigeneticeffectsofbutyrate:potential
therapeuticimplicationsforclinicalpractice
RobertoBerniCanani1,2*,MargheritaDiCostanzo1andLudovicaLeone1
Abstract
Butyrateisashortchainfattyacidderivedfromthemicrobialfermentationofdietaryfibersinthecolon.Inthelast
decade,multiplebeneficialeffectsofbutyrateatintestinalandextraintestinallevelhavebeendemonstrated.The
mechanismsofactionofbutyratearedifferentandmanyoftheseinvolveanepigeneticregulationofgene
expressionthroughtheinhibitionofhistonedeacetylase.Thereisagrowinginteres
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