The impact of bisphosphonates on the osteoblast proliferation and Collagen gene expression in vitro 英文参考文献.docVIP

Koch et al. Head Face Medicine 2010, 6:12 /content/6/1/12 HEAD FACE MEDICINE RESEARCH Open Access The impact of bisphosphonates on the osteoblast Research proliferation and Collagen gene expression in vitro Felix Peter Koch?1, Sareh Said Yekta?3, Christina Merkel1, Thomas Ziebart1 and Ralf Smeets*2 Abstract Background: Bisphosphonates are widely used in the clinical treatment of bone diseases with increased bone resorption. In terms of side effects, they are known to be associated with osteonecrosis of the jaw (BONJ). The objective of this study was to evaluate the effect of bisphosphonat