Three New Cycloartenol Triterpenoid Saponins from the Roots of Cimicifuga simplex Wormsk 英文参考文献.docVIP

Molecules 2011, 16, 4348-4357; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Three New Cycloartenol Triterpenoid Saponins from the Roots of Cimicifuga simplex Wormsk Haixue Kuang *, Yang Su, Bingyou Yang, Yonggang Xia, Qiuhong Wang, Zhibin Wang and Zhengfan Yu Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China * Author to whom correspondence should be addressed; E-Mail: hxkuang@; Tel.: +86-451 Fax: +86-451 Received: 3 May 2011; in revised form: 23 May 2011 / Accepted: 23 May 2011 / Published: 25 May 2011 Abstract: Three new cycloartenol triterpene saponins, named shengmaxinsides A-C, have been isolated from the ethyl acetate soluble fraction of an ethanol extract of Cimicifuga simplex Wormsk roots. Their structures were established by chemical tests and detailed spectroscopic analysis as 25-O-acetyl-7,8-didehydrocimigenol-3-O-β-D-galactopyranoside (1), 7,8-didehydrocimigenol-3-O-β-D-galactopyranoside (2) and 7,8-didehydro-24S-O- acetylhydroshengmanol-3-O-β-D-galactopyranoside (3), respectively. Keywords: Cimicifuga simplex Wormsk; 9,19-cyclanstane triterpenic glycosides; cycloartenol triterpenoid saponins 1. Introduction The Ranunculaceae is a small family with five genera and around 19 species found throughout the World. Currently, about nine Cimicifuga species grow in China. C. simplex (Shengma in Chinese) is a deciduous perennial herb widely distributed in China. Traditionally, the root of C. simplex has been used in oriental countries as an anti-inflammatory and anti-viral agent [1-3] and the beneficial ingredients responsible for the anti-inflammatory effects are ferulic acid and isoferulic acid [4,5]. This herb has also been used for the treatment of human immunodeficiency virus (HIV), and its more general analgesic, antipyretic,