Three New Steroidal Glycosides from the Roots of Cynanchum auriculatum 英文参考文献.docVIP

Molecules 2011, 16, 1901-1909; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Three New Steroidal Glycosides from the Roots of Cynanchum auriculatum Yu Lu 1, Hong-Li Teng 2, Guang-Zhong Yang 1 and Zhi-Nan Mei 1,* 1 Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, Wuhan 430074, China 2 Guangxi Institute of Minority Medicine, Nanning 530001, China * Authors to whom correspondence should be addressed; E-Mail: meizhinan@163.com; Tel.: 86-27 Fax: 86-27 Received: 15 November 2010; in revised form: 16 February 2011 / Accepted: 18 February 2011 / Published: 23 February 2011 Abstract: Three new steroidal glycosides, cyanoauriculosides F, G and H (1-3), were isolated from the roots of Cynanchum auriculatum (Asclepiadaceae) along with two known steroidal derivatives. On the basis of spectroscopic analysis and chemical methods, their structures were identified as 20-O-acetyl-8,14-seco-penupogenin-8-one 3-O-α-L- cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D- cymaropyranoside (1), 2′,3′-Z-gagaminine 3-O-α-L-cymaropyranosyl-(1→4)-β-D-cymaro- pyranosyl-(1→4)-α-L-diginopyranosyl-(1→4)-β-D-cymaropyranoside (2), 17-O-acetyl- kidjoranin 3-O-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-cymaro- pyranosyl-(1→4)-β-D-digitoxopyranosyl-(1→4)-β-D-digitoxopyranoside (3), gagaminine 3-O-α-L-cymaropyranosyl-(1→4)-β-D-cymaropyranosyl-(1→4)-α-L-digino-pyranosyl- (1→4)-β-D-cymaropyranoside (4) and wilfoside D1N (5). Keywords: Cynanchum auriculatum; steroidal glycosides; cyanoauriculosides 1. Introduction Cynanchum auriculatum is a famous traditional medicine widely used in south China for the prevention of hair graying, strengthening sinews and bones, and enhancing immunity [1]. In previous papers, we reported the isolation of five new C-21 steroidal glycosides, named