Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis 英文参考文献.docVIP

Available online /content/13/3/R64 Research Open Access Vol 13 No 3 Time course of angiopoietin-2 release during experimental human endotoxemia and sepsis Philipp Kümpers1*, Matijs van Meurs2,3*, Sascha David1, Grietje Molema3, Johan Bijzet3, Alexander Lukasz1, Frank Biertz4, Hermann Haller1 and Jan G Zijlstra2 1Department of Nephrology Hypertension, Hannover Medical School, Carl-Neuberg-Stra?e 1, 30625 Hannover, Germany 2Department of Critical Care, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands 3Department of Pathology and Medical Biology, University Medical Center Groningen, Hanzeplein 19713 GZ Groningen, The Netherlands 4Department of Biometrics, Hannover Medical School, Carl-Neuberg-Stra?e 1, 30625 Hannover, Germany * Contributed equally Corresponding author: Philipp Kümpers, kuempers.philipp@mh-hannover.de Received: 12 Feb 2009 Revisions requested: 3 Apr 2009 Revisions received: 21 Apr 2009 Accepted: 5 May 2009 Published: 5 May 2009 Critical Care 2009, 13:R64 (doi:10.1186/cc7866) This article is online at: /content/13/3/R64 ? 2009 Kümpers et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Endothelial activation leading to vascular barrier breakdown denotes a devastating event in sepsis. Angiopoietin (Ang)-2, a circulating antagonistic ligand of the endothelial specific Tie2 receptor, is rapidly released from Weibel-Palade and has been identified as a non-redundant gatekeeper of endothelial activation. We aimed to study: the time course of Ang-2 release during human experimental endotoxemia; the association of Ang-2 with soluble adhesion molecules and inflammatory cytokines; and the early time course of Ang-2 releas