Tissue saturation measurement - exciting prospects, but standardisation and reference data still needed 英文参考文献.docVIP

Jones and Terblanche Critical Care 2010,14:169 /content/14/3/169 COMMENTARY Tissue saturation measurement - exciting prospects, but standardisation and reference data still needed Nicola Jones and Marius Terblanche * 1 1,2 See related research by Mo?ina and Podbregar, /content/14/2/R42 SvO and signi? cant tissue hypoxia. e current study Abstract 2 suggests a means to identify these discrepancies which may be useful in the management of sepsis/septic shock, particularly in patients with complex haemodynamic distur bances. However, several issues relating to methodo logical factors require further consideration. Microcirculatory perfusion and tissue oxygen utiliza- Sepsis and shock result in disturbances in microcirculatory perfusion and tissue oxygen utilisation that may not be re?ected in global measures of haemodynamics. Near-infrared spectroscopy enables measurement of tissue oxygen saturation (StO2) and provides information on local microvascular and mitochondrial function. This measure could be incorporated with existing targets of goal-directed therapy to provide an integrated approach to haemodynamic resuscitation of both the macro- and microcirculation in various shock states. However, key methodological factors must be addressed before widespread clinical application. tion are a? ected by sepsis and shoc ese derange- ments can be studied non-invasively using near-infrared spectroscopy, a technique that is able to determine the oxygenation status of tissue haemoglobin. Decreased StO re? ects the presence of severe hypoperfusion and 2 has been used clinically to guide resuscitation during hypovolaemic shock [5]. Unfortunately, in sepsis/septic shock absolute values of StO do not reliably di? erentiate 2 patients from healthy individuals [6]. e discriminatory power and predictive ability of StO2 can,