Total calcium absorption is similar from infant formulas with and without prebiotics and exceeds that in human milk-fed infants 英文参考文献.docVIP

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Total calcium absorption is similar from infant formulas with and without prebiotics and exceeds that in human milk-fed infants 英文参考文献.doc

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Total calcium absorption is similar from infant formulas with and without prebiotics and exceeds that in human milk-fed infants 英文参考文献

Hicksetal.BMCPediatrics2012,12:118 /1471-2431/12/118 RESEARCH ARTICLE OpenAccess Totalcalciumabsorptionissimilarfrominfant formulaswithandwithoutprebioticsand exceedsthatinhumanmilk-fedinfants PenniDHicks1,2,3*,KeliMHawthorne1,2,CarolLBerseth3,JohnDMarunycz3,JamesEHeubi4 andStevenAAbrams1,2 Abstract Background:1)Toevaluatecalciumabsorptionininfantsfedaformulacontainingprebiotics(PF)andonewithout prebiotics(CF).2)Tocomparecalciumabsorptionfromtheseformulaswithagroupofhumanmilk-fed(HM) infants. Methods:AdualtracerstableisotopemethodwasusedtoassesscalciumabsorptionininfantsexclusivelyfedCF (n=30),PF(n=25)orHM(n=19).Analysisofvariancewasusedtoanalyzecalciumintake,fractionalcalcium absorption,andtheamountofcalciumabsorbed. Results:Calciumintake(Mean±SEM)forPFwas534±17mg/dand557±16mg/dforCF(p=0.33).Fractional calciumabsorptionwas56.8±2.6%forPFand59.2±2.3%forCF(p=0.49).TotalcalciumabsorbedforPFwas 300±14mg/dand328±13mg/dforCF(p=0.16).ForHMinfantscalciumintakewas246±20mg/d,fractional calciumabsorptionwas76.0±2.9%andtotalcalciumabsorbedwas187±16mg/d(p0.001,comparedtoeither PForCF). Conclusions:DespitelowerfractionalcalciumabsorptionofCFandPFcomparedtoHM,highercalciumcontentin bothledtohighertotalcalciumabsorptioncomparedtoHMinfants.Nosignificanteffectofprebioticswas observedoncalciumabsorptionorothermarkersofbonemineralmetabolism. Background absorbedfromanyinfantformulaisatleastequaltothat The standard for nutrient intake and bioavailability in provided by HM and to evaluate calcium absorption as thefirstmonthsoflifeistheexclusivelyhumanmilk-fed changesaremadetoinfantformulacomposition. infant. Because ofthe possibility oflower bioavailability, Prebiotics are currently routinely added to infant for- the quantity of minerals important for bone develop- mulas. A prebiotic is a non-digestible food ingredient ment, including calcium, in infant formulas are greater that brings about specific changes in the composition than those found in human milk (HM). Concentration a