Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis a case control study followed by a randomized double-blind controlled trial 英文参考文献.docVIP

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Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis a case control study followed by a randomized double-blind controlled trial 英文参考文献.doc

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Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis a case control study followed by a randomized double-blind controlled trial 英文参考文献

Available online /content/11/6/R117 Research Open Access Vol 11 No 6 Tranexamic acid attenuates inflammatory response in cardiopulmonary bypass surgery through blockade of fibrinolysis: a case control study followed by a randomized double-blind controlled trial Juan J Jimenez1, Jose L Iribarren1, Leonardo Lorente1, Jose M Rodriguez2, Domingo Hernandez3, Ibrahim Nassar4, Rosalia Perez1, Maitane Brouard1, Antonio Milena5, Rafael Martinez4 and Maria L Mora1 1Intensive Care Department, Hospital Universitario de Canarias, Ofra s/n La Cuesta, La Laguna, 38320, Spain 2Hematology Department, Hospital Universitario de Canarias, Ofra s/n La Cuesta, La Laguna, 38320, Spain 3Research Unit, Hospital Universitario de Canarias, Ofra s/n La Cuesta, La Laguna, 38320, Spain 4Cardiac Surgery Department, Hospital Universitario de Canarias, Ofra s/n La Cuesta, La Laguna, 38320, Spain 5Biochemistry and Central Laboratories, Hospital Universitario de Canarias, Ofra s/n La Cuesta, La Laguna, 38320, Spain Corresponding author: Juan J Jimenez, jjjimenezrivera@ Received: 17 Jul 2006 Revisions received: 25 May 2007 Accepted: 7 Nov 2007 Published: 7 Nov 2007 Critical Care 2007, 11:R117 (doi:10.1186/cc6173) This article is online at: /content/11/6/R117 ? 2007 Jimenez et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Extracorporeal circulation induces hemostatic independent protective variable (odds ratio 0.38, 95% confidence interval 0.18 to 0.81; P 0.01). The clinical trial was interrupted. Fifty patients were randomly assigned to receive TA (24) or placebo (26). Incidence of IR was 17% in the TA group versus 42% in the placebo group (P = 0.047). In the TA group, we observed a significant reduction in the incid