Towards patient-specific cardiovascular modeling system using the immersed boundary technique 英文参考文献.docVIP

Tayetal.BioMedicalEngineeringOnLine2011,10:52 /content/10/1/52 RESEARCH OpenAccess Towardspatient-specificcardiovascularmodeling systemusingtheimmersedboundarytechnique Wee-BengTay1,Yu-HengTseng1*,Liang-YuLin2andWen-YihTseng3 *Correspondence:YHTseng@as. Abstract .tw 1HighPerformanceComputing EnvironmentalFluidDynamic Laboratory,Departmentof Background:Previousresearchshowsthattheflowdynamicsintheleftventricle (LV)revealimportantinformationaboutcardiachealth.Thisinformationcanbeused AtmosphericSciences,National TaiwanUniversity,Taipei,Taiwan Fulllistofauthorinformationis availableattheendofthearticle inearlydiagnosisofpatientswithpotentialheartproblems.Thecurrentstudy introducesapatient-specificcardiovascular-modellingsystem(CMS)whichsimulates theflowdynamicsintheLVtofacilitatephysiciansinearlydiagnosisofpatients beforeheartfailure. Methods:Theproposedsystemwillidentifypossiblediseaseconditionsand facilitatesearlydiagnosisthroughhybridcomputationalfluiddynamics(CFD) simulationandtime-resolvedmagneticresonanceimaging(4-DMRI).Thesimulation isbasedonthe3-Dheartmodel,whichcansimultaneouslycomputefluidand elasticboundarymotionsusingtheimmersedboundarymethod.Atthispreliminary stage,the4-DMRIisusedtoprovideanappropriatecomparison.Thisallowsflexible investigationoftheflowfeaturesintheventriclesandtheirresponses. Results:Theresultssimulatevariousflowratesandkineticenergyinthediastoleand systolephases,demonstratingthefeasibilityofcapturingsomeoftheimportant characteristicsoftheheartduringdifferentphases.However,somediscrepancies existinthepulmonaryveinandaortaflowratebetweenthenumericaland experimentaldata.Furtherstudiesareessentialtoinvestigateandsolvethe remainingproblemsbeforeusingthedatainclinicaldiagnostics. Conclusions:Theresultsshowthatbyusingasimplereservoirpressureboundary condition(RPBC),weareabletocapturesomeessentialvariationsfoundinthe clinicaldata.Ourapproachestablishesafirst-stepframeworkofapracticalpatient- specificCMS,whichcomprisesa3-DCFDmodel(withoutinvolv