Transcription of the genome dont read it all at once 英文参考文献.docVIP

/2001/2/4/reports/4008.1 Meeting report Transcription of the genome: don’t read it all at once Merlin Crossley Address: Department of Biochemistry, University of Sydney, New South Wales, 2006, Australia. E-mail: M.Crossley@.au Published: 4 April 2001 GenomeBiology 2001, 2(4):reports4008.1–4008.3 The electronic version of this article is the complete one and can be found online at /2001/2/4/reports/4008 ? BioMed Central Ltd (Print ISSN 1465-6906; Online ISSN 1465-6914) important information on function. Mitch Weiss (Children?s A report on the 22nd Annual Lorne Conference on the Hospital of Philadelphia, USA) explained how the molecular Organization and Expression of the Genome, Lorne, Victoria, basis for an inherited human anemia was revealed by Australia, 11-15 February, 2001 sequencing a candidate gene encoding the GATA-1 tran- scription factor. The mutation is in the amino-terminal zinc finger of GATA-1 and reduces its interaction with its cofac- With the availability of vast amounts of genomic sequence, many new opportunities have arisen. Speakers at this Lorne Conference reported opportunities for identifying important genes, understanding global mechanisms of expression, and controlling gene output. tor, riend of GATA. It is likely that mutations in regulatory proteins (and particularly zinc-finger proteins, which are particularly abundant) will give rise to many viable and interesting human phenotypes. Another method for identifying useful genes is expression profiling. Paul Meltzer (National Human Genome Research Institute, Bethesda, USA) has been working with cDNA microarrays. He has focussed on four related tumor types - Burkitt?s lymphoma, Ewing?s sarcoma, neuroblastoma and rhabdosarcoma - in an effort to identify genes that are differ- entially expressed between these tumors and are diagnosti- cally characteristic of each. Although there is some diversit