Transcriptional and Functional Analysis Shows Sodium Houttuyfonate-Mediated Inhibition of Autolysis in Staphylococcus aureus 英文参考文献.docVIP

Molecules 2011, 16, 8848-8865; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Transcriptional and Functional Analysis Shows Sodium Houttuyfonate-Mediated Inhibition of Autolysis in Staphylococcus aureus Guoxing Liu 1,?, Hua Xiang 1,?, Xudong Tang 4,?, Kaiyu Zhang 5,?, Xiuping Wu 1,?, Xuelin Wang 1,?, Na Guo 2,?, Haihua Feng 1,?, Guangming Wang 1,?, Lihui Liu 1,?, Qiyun Shi 1,?, Fengge Shen 1, Mingxun Xing 1, Peng Yuan 1, Mingyuan Liu 1,* and Lu Yu 1,3,* 1 Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, China 2 Department of Food Quality and Safety, College of Quartermaster Technology, Jilin University, Changchun 130062, China 3 State Key Laboratory for Molecular Virology and Genetic Engineering, Chinese Center for Disease Control and Prevention, Beijing 100176, China 4 Key Lab for New Drug Research of TCM, Research Institute of Tsinghua University in Shenzhen, Shenzhen 518057, China 5 Department of Infectious Diseases, First Hospital of Jilin University, Changchun 130021, China ? These authors contributed equally to this work. * Authors to whom correspondence should be addressed; E-Mails: yulu225@ (L.Y.); liumy36@163.com (M.L.); Tel.: +86-431(L.Y.); +86-431(M.L.); Fax: +86-431(L.Y.); +86-431(M.L.); Received: 13 October 2011 / Accepted: 17 October 2011 / Published: 21 October 2011 Abstract: Sodium houttuyfonate (SH), an addition compound of sodium bisulfite and houttuynin, showed in vitro antibacterial activity against 21 Staphylococcus aureus (S. aureus) strains grown in planktonic cultures. Microarray results showed decreased levels of autolysin atl, sle1, cidA and lytN transcripts in the SH-treated strain as compared to the control strain, consistent with the induction of the autolytic repressors lrg