Unraveling the genomic diversity of small eukaryotes 英文参考文献.docVIP

Meeting report Unraveling the genomic diversity of small eukaryotes Gilles Fischer*, Dawn Thompson?, Jennifer Russo Wortman? and Cécile Fairhead§ Addresses: *Microorganism Genomics, UPMC/CNRS FRE3214, Paris, France. ?Broad Institute, Cambridge, MA 02139, USA. ?Institute for Genome Sciences, University of Maryland, School of Medicine, Baltimore, MD 21201, USA. §Institut de Génétique et Microbiologie, Université Paris Sud 11, CNRS UMR8621, Orsay, France. Correspondence: Cécile Fairhead. Email: cecile.fairhead@u-psud.fr have largely been overlooked until recent advances in genomic technology. These eukaryotic microbes represent human and plant pathogens, as well as species of industrial and agricultural importance and key model organisms. Abstract A report of the meeting Comparative Genomics of Eukaryotic Microorganisms, 17-22 October 2009, San Feliu de Guixols, Spain. The first meeting in a new series of EMBO meetings aimed at bringing together those working on genome-enabled research encompassing the great diversity of eukaryotic Sex and hybridization in yeasts and other fungi Sexual reproduction is almost universal in eukaryotes and the diverse mating systems of fungi provide insights into its evolution. Joseph Heitman (Duke University, Durham, USA) raised the issue of the adaptive importance of the sexual cycle - indeed, asexual or rarely sexual species seem to be evolutionary dead ends. As he noted, one obvious benefit of sex is to increase genetic diversity. However, many fungal species have developed sophisticated mecha- nisms for selfing that, paradoxically, provide no oppor- tunity for genetic exchange. In Aspergillus nidulans, for microorganisms was as held high-throughput sequencing recently in Spain. New now technology such allows less well studied eukaryotic microbes to come into the limelight, providing some fascina