Understanding immune dysfunctions in sepsis patients 英文参考文献.docVIP

López-Collazo et al. Critical Care 2010, 14:435 /content/14/4/435 LET TER Understanding immune dysfunctions in sepsis patients Eduardo López-Collazo *, Vanesa Gómez-Pi?a and Francisco Arnalich * 1 1 2 See related research by Gogos et al., /content/14/3/R96 We read with interest the article by Gogos and colleagues (NF-κB2/p100, NF-κB-inducing kinase, lymphotoxin β- in a previous issue of Critical Care reporting that there are receptor, v-rel reticuloendotheliosis viral oncogene major di? erences in the early status of the innate and homo logue A (p65) and serine/threonine protein kinase). adaptative immune responses between sepsis and severe sepsis/shock in relation to the underlying type of infec tion ese data suggest an alternative activation of their innate immune cells as occurs in endotoxin tolerance. In [1]. In patients with acute pyelonephritis and intra- contrast, we observed a negative regulation of several abdominal infection, expression of HLA-DR on mono- genes of lymphocytes such as T-cell antigen receptor, cytes was signi? cantly decreased among patients with linked for activation of T cells, and ΔCD3–TCR complex severe sepsis/shock compared with among patients only (Figure 1g to ese results are in line with previous is di? erence was related to an un- observations that patients who su? er from an endotoxin tolerance have an impaired immune adaptative system [3,4]. su? ering sepsis. favourable outcome in patients with acute pyelo nephritis. e authors considered the decrease of CD14/HLA-DR co-expression to be an index of immunoparalysis and bad e analysis of several parameters of the immune prognosis [1]. An altered expression of HLA-DR on the response (exp