Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis 英文参考文献.docVIP

Molecules 2009, 14, 3844-3850; doi:10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /journal/molecules Article Ugandenial A, a New Drimane-type Sesquiterpenoid from Warburgia ugandensis Min Xu 1, Marc Litaudon 2,*, Sabrina Krief 3, Marie-Thérèse Martin 2, John Kasenene 4, Bernard Kiremire 5, Vincent Dumontet 2 and Fran?oise Guéritte 2 1 Kunming Institute of Botany, Chinese Academy of Sciences, Heilongtan, Kunming 650204, China; E-Mail: xumin@ (M.X.) 2 Institut de Chimie des Substances Naturelles, UPR2301, CNRS, 91198 Gif-sur-Yvette cedex, France; E-Mails: mtm@rs-gif.fr (M-T.M.); vincent.dumontet@rs-gif.fr (V.D.); francoise.gueritte@rs-gif.fr (F.G.) 3 UMR 7206-USM 104 Eco-anthropologie et ethnobiologie, MNHN, 75231 Paris cedex, France; E-Mail: krief@mnhn.fr (S.K.) 4 Department of Botany, Makerere University, Box 7062, Kampala, Uganda; E-Mail: botany@botany.mak.ac.ug (J.K.) 5 Chemistry Department, Makerere University, Box 7062, Kampala, Uganda; E-Mail: kiremire@chemistry.mak.ac.ug (B.K.) * Author to whom correspondence should be addressed; E-Mail: litaudon@rs-gif.fr. Received: 28 August 2009; in revised form: 21 September 2009 / Accepted: 25 September 2009 / Published: 28 September 2009 Abstract: One new drimane-type sesquiterpenoid, named ugandenial A (1), was isolated from the ethyl acetate extract of the bark of Warburgia ugandensis (Canellaceae) together with eight known drimane-type sesquiterpenoids: 11α-hydroxycinnamosmolide (2), warburganal (3), polygodial (4), mukaadial (5), dendocarbin A (6), 9α-hydroxycinnamolide (7), dendocarbin L (8) and dendocarbin M (9). Their structures were established by detailed spectroscopic analysis. In addition a keto-enol equilibrium was demonstrated for compound 1 through a detailed NMR analysis run in CD2Cl2 at 190 K. Cytotoxicity of the isolated compounds against KB cells was evaluated. Keywords: Warburgia ugandensis; drimane-type sesquiterpenoid; ugandenial; cytotoxi