Understanding embryonic development from screens to genes 英文参考文献.docVIP

Meeting report Understanding embryonic development: from screens to genes Lisa A Taneyhill Address: Division of Biology, California Institute of Technology, Pasadena, CA 91125, USA. E-mail: ltaney@ Published: 24 November 2005 Genome Biology 2005, 6:359 (doi:10.1186/gb-2005-6-12-359) The electronic version of this article is the complete one and can be found online at /2005/6/12/359 ? 2005 BioMed Central Ltd (partitioning-defective) proteins. CHP-1 normally localizes to A report on the 64th Annual Meeting of the Society for Developmental Biology, San Francisco, USA, 27 July- 1 August 2005. the cytoplasm and is thought to play a role in degrading those PAR proteins with anterior localization; the chp-1 RNAi phe- notype shows symmetric cell division. The CK1 RNAi pheno- type leads to the production of an asymmetric, unstable spindle such that both pronuclei go to the anterior end of the cell. Casein kinase 1 normally localizes to the asters and has a punctate distribution in the cytoplasm, helping to position the spindle through forces that involve the activity of the G-protein regulators GPR-1 and GPR-2 (GPR1/2). CK1 func- tions upstream of phosphatidylinositol-4-phosphate 5-kinase (PPK-1), a protein that generates phosphatidylinositol diphos- The elucidation of the complete genome sequences of various model organisms, in conjunction with the develop- ment of new screening methods, provides a type of func- tional genomics that has been unavailable to developmental biologists in the past. The collaboration between novel com- putational and molecular biological techniques and tradi- tional embryology was evident in the outstanding research presented at the annual meeting of the Society for Develop- mental Biology held in San Francisco this summer. The underlying theme of the meeting was how a partnering between different disciplines can