Update on biological therapeutics for asthma 英文参考文献.docVIP

BASIC ANDCLINICALTRANSLATIONALSCIENCE INALLERGY,ASTHMA ANDIMMUNOLOGY REVIEWSERIES UpdateonBiologicalTherapeuticsforAsthma MarishaL.Cook,MD,andBruceS.Bochner,MD guidelinesofferinadequateassistanceinthemanagementof Abstract: Asthma poses a signi?cant burden on patients, families, severe refractory asthmatic patients, in part because of a healthcareproviders,andthemedicalsystem.Whileeffortstostan- paucityofothertreatmentoptions.Novelbiologictherapeu- dardizecarethroughguidelineshaveexpanded,dif?cultyinmanaging ticsarebeingdevelopedforthetreatmentofasthmaandare severe asthma has encouraged research about its pathobiology and of potential use for severe refractory asthma, especially treatmentoptions.Novelbiologictherapeuticsarebeingdevelopedfor where the increased cost of such agents is more likely thetreatmentofasthmaandareofpotentialuseforsevererefractory justi?ed.Thisreviewwillbrie?ysummarizewhatismeantby asthma, especially where the increased cost of such agents is more “biologictherapies”andthenhighlightrecentpublisheddata likelyjusti?ed.Thisreviewwillsummarizecurrentlyapproved(oma- onef?cacyandsafetyofthesetherapiesforasthma. lizumab)andinvestigationalbiologicagentsforasthma,suchasanti- bodies, soluble receptors, and other protein-based antagonists, and highlightrecentpublisheddataonef?cacyandsafetyofthesetherapies WHATAREBIOLOGICTHERAPIES? Biologictherapieshaverevolutionizedthetreatmentof many diseases including asthma. By de?nition, the term “biologics” or “biologicals” include a variety of protein- basedtherapeutics,suchasantibodies,solublereceptors(eg, etanercept), recombinant protein-based receptor antagonists (eg, pitrakinra) and other related structures. Their main ad- vantages include the duration of action and highly speci?c andstrongbindingtothetargetofinterest;theirmaindisad- vantagesarethecostandneedforparenteraladministration. Mostbiologicalsinclinicaluseareantibodies,andtheir inhumans.Astheseneweragentswithhighlytargetedpharmacology aretestedinasth