Urticaria and infections 英文参考文献.docVIP

Allergy, Asthma Clinical Immunology BioMedCentral Review Open Access Urticaria and infections Bettina Wedi*, Ulrike Raap, Dorothea Wieczorek and Alexander Kapp Address: Department of Dermatology and Allergy, Hannover Medical School, Hannover, Germany Email: Bettina Wedi* - wedi.bettina@mh-hannover.de; Ulrike Raap - raap.ulrike@mh-hannover.de; Dorothea Wieczorek - wieczorek.dorothea@mh-hannover.de; Alexander Kapp - kapp.alexander@mh-hannover.de * Corresponding author Published: 1 December 2009 Received: 29 October 2009 Accepted: 1 December 2009 Allergy, Asthma Clinical Immunology 2009, 5:10 doi:10.1186/1710-1492-5-10 This article is available from: /content/5/1/10 ? 2009 Wedi et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Urticaria is a group of diseases that share a distinct skin reaction pattern. Triggering of urticaria by infections has been discussed for many years but the exact role and pathogenesis of mast cell activation by infectious processes is unclear. In spontaneous acute urticaria there is no doubt for a causal relationship to infections and all chronic urticaria must have started as acute. Whereas in physical or distinct urticaria subtypes the evidence for infections is sparse, remission of annoying spontaneous chronic urticaria has been reported after successful treatment of persistent infections. Current summarizing available studies that evaluated the course of the chronic urticaria after proven Helicobacter eradication demonstrate a statistically significant benefit compared to untreated patients or Helicobacter-negative controls without urticaria (p 0.001). Since infections can be easily treated some diagnostic procedures should be inclu