Use of a doxycycline-enrofloxacin-metronidazole combination withwithout diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni 英文参考文献.docVIP

Lin and Huang Acta Veterinaria Scandinavica 2010, 52:27 /content/52/1/27 BRIEF COMMUNICATION Open Access Use of a doxycycline-enrofloxacin-metronidazole Brief communication combination with/without diminazene diaceturate to treat naturally occurring canine babesiosis caused by Babesia gibsoni Ming-Yu Lin1 and Hui-Pi Huang*1,2 Abstract Canine babesiosis is an important worldwide, tick-borne disease caused by hemoprotozoan parasites of the genus Babesia. Babesia gibsoni is the predominant species that causes canine babesiosis in Taipei, Taiwan. It is a small pleomorphic intraerythrocytic parasite that can cause erythrocyte destruction and hemolytic anemia. Efficacy of oral administration of a doxycycline-enrofloxacin-metronidazole combination with and without injections of diminazene diaceturate in the management of naturally occurring canine babesiosis caused by B. gibsoni was evaluated retrospectively. The overall efficacy of this combination of doxycycline-enrofloxacin-metronidazole in conjunction with and without administration of diminazene diaceturate was 85.7% and 83.3%, respectively; with a mean recovery time of 24.2 and 23.5 days, respectively. Concomitant use of intramuscular diminazene diaceturate may not improve the efficacy of a doxycycline-enrofloxacin-metronidazole combination in management of canine babesiosis caused by B. gibsoni. Findings and detection of amplification of nucleic acid extracted from blood or tissues [4,5,15]. Canine babesiosis is an important worldwide, tick-borne disease caused by hemoprotozoan parasites of the genus Babesia, and the predominant species infecting dogs is B. Many drugs have been applied in management of canine babesiosis, including babesiacidal agents (dimina- vogeli [1]. In a previous study, B. gibsoni was found to be zene aceturate, imidocarb diproprionate), antibiotics the major causative agent of canine babesiosis in Taipei, (azithromycin, clindamycin, doxycycline, met