Use of a beta microprobe system to measure arterial input function in PET via an arteriovenous shunt in rats 英文参考文献.docVIP

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Use of a beta microprobe system to measure arterial input function in PET via an arteriovenous shunt in rats 英文参考文献.doc

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Use of a beta microprobe system to measure arterial input function in PET via an arteriovenous shunt in rats 英文参考文献

Warnocketal.EJNMMIResearch2011,1:13 /content/1/1/13 ORIGINAL RESEARCH OpenAccess Useofabetamicroprobesystemtomeasure arterialinputfunctioninPETviaanarteriovenous shuntinrats GeoffWarnock1*,Mohamed-AliBahri1,DavidGoblet1,FabriceGiacomelli1,ChristianLemaire1,JoelAerts1, AlainSeret3,XavierLanglois2,AndreLuxen1andAlainPlenevaux1 Abstract Background:Kineticmodelingofphysiologicalfunctionusingimagingtechniquesrequirestheaccurate measurementofthetime-activitycurveofthetracerinplasma,knownasthearterialinputfunction(IF).The measurementofIFcanbeachievedthroughmanualbloodsampling,theuseofsmallcountingsystemssuchas betamicroprobes,orbyderivationfromPETimages.Previousstudiesusingbetamicroprobesystemsto continuouslymeasureIFhavesufferedfromhighbackgroundcounts. Methods:Inthepresentstudy,alight-insensitivebetamicroprobewithatemporalresolutionofupto1swas usedincombinationwithapump-drivenfemoralarteriovenousshunttomeasureIFinrats.Theshuntapparatus wasdesignedsuchthattheplacementofthebetamicroprobewashighlyreproducible.Theprobe-derivedIFwas comparedtothatobtainedfrommanualsamplingat5-sintervalsandIFderivedfromaleftventricleVOIina dynamicPETimageoftheheart. Results:Probe-derivedIFswereverywellmatchedtothatobtainedby“goldstandard”manualbloodsampling, butwithanincreasedtemporalresolutionofupto1s.Theareaunderthecurve(AUC)ratiobetweenprobe-and manuallyderivedIFswas1.07±0.05withacoefficientofvariationof0.04.However,image-derivedIFswere significantlyunderestimatedcomparedtothemanuallysampledIFs,withanAUCratioof0.76±0.24witha coefficientofvariationof0.32. Conclusions:IFderivedfromthebetamicroprobeaccuratelyrepresentedtheIFasmeasuredbybloodsampling, wasreproducible,andwasmoreaccuratethananimage-derivedtechnique.Theuseoftheshuntremoved problemsoftissue-backgroundactivity,andtheuseofalight-tightprobewithminimalgammasensitivityrefined thesystem.Theprobe/shuntapparatuscanbeusedinbothmicroprobeandPETstudies. Keywords:betamicroprobe,arterialinputfunction,PET,rat Background thetime-activitycurveo