Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladder 英文参考文献.docVIP
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Unusual finding of endocervical-like mucinous epithelium in continuity with urothelium in endocervicosis of the urinary bladder 英文参考文献
Cheahetal.DiagnosticPathology2011,6:56
/content/6/1/56
CASE REPORT
OpenAccess
Unusualfindingofendocervical-likemucinous
epitheliumincontinuitywithurotheliumin
endocervicosisoftheurinarybladder
Phaik-LengCheah1*?,Lai-MengLooi1?,GeorgeEng-GeapLee2?,Kean-HooiTeoh1?,Kein-SeongMun1?and
AbdulRahmanNazarina1?
Abstract
Endocervicosisintheurinarybladderisararebenigncondition.Wepresentacaseina37-year-oldwomanwith
classicalclinicalandpathologicalfeaturesofendocervicosis.Theunusualobservationofendocervical-likemucinous
epitheliumincontinuitywiththeurotheliuminadditiontofullydevelopedendocervicosisprompted
immunohistochemicalprofilingofthecaseusingantibodiestocytokeratins(AE1/AE3,CK19,CK7,CK5/6,CK20),
HBME-1,estrogenreceptor(ER)andprogesteronereceptor(PR)toassesstherelationshipofthesurfacemucinous
andendocervicosisglandularepithelia.Thesurfacemucinousepithelium,urotheliumandendocervicosisglands
wereimmunopositiveforAE1/AE3,CK7andCK19whileCK20wasonlyexpressedbyfewurothelialumbrellacells.
ThesurfacemucinousepitheliumwasCK5/6andHBME-1immunonegativebutshowedpresenceofERandPR.
Thiswasincontrasttotheurothelium’sexpressionofCK5/6butnotERandPR.Incomparison,endocervicosis
glandsexpressedHBME-1,unlikethesurfacemucinousepithelium.Theendocervicosisepitheliumalso
demonstratedtheexpectedpresenceofERandPRandCK5/6immunonegativity.Theslightlydiffering
immunohistochemicalphenotypesofthesurfacemucinousandmorphologicallysimilarendocervicosisglandular
epitheliumisinterestingandrequiresfurtherclarificationtoitsactualnature.Thepatienthasremainedwelland
withoutevidenceofdisease18-monthsfollowingtransurethralresectionofthelesion.
VirtualSlides:Thevirtualslide(s)forthisarticlecanbefoundhere:http://www.diagnosticpathology.diagnomx.eu/
vs/2840395525426177.
Background
the posterior bladder wall, endocervicosis is generally
Endocervicosis in the urinary bladder is a rare benign thoughttobeanembryologicaldisorderofthesecond-
condition, first recognised by Steele andByrne in 1982 ary mullerian system [6,7]
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