Virus-Induced Aggregates in Infected Cells 英文参考文献.docVIP

Viruses 2012, 4, 2218-2232; doi:10.3390/v4102218 OPEN ACCESS viruses ISSN 1999-4915 /journal/viruses Review Virus-Induced Aggregates in Infected Cells Adi Moshe and Rena Gorovits * Institute of Plant Sciences and Genetics in Agriculture and the Otto Warburg Minerva Center for Agricultural Biotechnology, The Robert H. Smith Faculty of Agriculture, Food and Environment, The Hebrew University of Jerusalem, Rehovot 76100, Israel; E-Mail: adisara.moshe@mail.huji.ac.il * Author to whom correspondence should be addressed; E-Mail: gorovits@agri.huji.ac.il; Tel.: +972-8- 9489389; Fax: +972-8- 9363882. Received: 29 August 2012; in revised form: 27 September 2012 / Accepted: 29 September 2012 / Published: 17 October 2012 Abstract: During infection, many viruses induce cellular remodeling, resulting in the formation of insoluble aggregates/inclusions, usually containing viral structural proteins. Identification of aggregates has become a useful diagnostic tool for certain viral infections. There is wide variety of viral aggregates, which differ by their location, size, content and putative function. The role of aggregation in the context of a specific virus is often poorly understood, especially in the case of plant viruses. The aggregates are utilized by viruses to house a large complex of proteins of both viral and host origin to promote virus replication, translation, intra- and intercellular transportation. Aggregated structures may protect viral functional complexes from the cellular degradation machinery. Alternatively, the activation of host defense mechanisms may involve sequestration of virus components in aggregates, followed by their neutralization as toxic for the host cell. The diversity of virus-induced aggregates in mammalian and plant cells is the subject of this review. Keywords: plant virus; mammalian virus; aggregation  Viruses 2012, 4 2219 1. Introduction Increasing evidence suggests that the assembly of many