Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering 英文参考文献.docVIP

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Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering 英文参考文献.doc

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Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering 英文参考文献

Materials 2010, 3, 2346-2368; doi:10.3390/ma3042346 OPEN ACCESS materials ISSN 1996-1944 /journal/materials Article Versatile Biodegradable Poly(ester amide)s Derived from α-Amino Acids for Vascular Tissue Engineering Pooneh Karimi 1, Amin S. Rizkalla 1,2,* and Kibret Mequanint 1,* 1 Department of Chemical and Biochemical Engineering, The University of Western Ontario, London, ON, Canada; E-Mail: pkarimib@uwo.ca (P.K.) 2 Division of Biomaterials Science, Schulich School of Medicine and Dentistry, The University of Western Ontario, London, ON, Canada * Authors to whom correspondence should be addressed; E-Mails: arizkalla@eng.uwo.ca (A.S.R.); kmequani@eng.uwo.ca (K.M.); Tel.: +1-519-611-2111 ext 88573; Fax: +1-519-661-3498. Received: 4 January 2010; in revised form: 6 March 2010 / Accepted: 16 March 2010 / Published: 26 March 2010 Abstract: Biodegradable poly(ester amide) (PEA) biomaterials derived from α-amino acids, diols, and diacids are promising materials for biomedical applications such as tissue engineering and drug delivery because of their optimized properties and susceptibility for either hydrolytic or enzymatic degradation. The objective of this work was to synthesize and characterize biodegradable PEAs based on the α-amino acids L-phenylalanine and L- methionine. Four different PEAs were prepared using 1,4-butanediol, 1,6-hexanediol, and sebacic acid by interfacial polymerization. High molecular weight PEAs with narrow polydispersity indices and excellent film-forming properties were obtained. The incubation of these PEAs in PBS and chymotrypsin indicated that the polymers are biodegradable. Human coronary artery smooth muscle cells were cultured on PEA films for 48 h and the results showed a well-spread morphology. Porous 3D scaffolds fabricated from these PEAs were found to have excellent porosities indicating the utility of these polymers for vascular tissue engineering. Keywords: biodegradable