Violating the splicing rules TG dinucleotides function as alternative 3 splice sites in U2-dependent introns 英文参考文献.docVIP

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Violating the splicing rules TG dinucleotides function as alternative 3 splice sites in U2-dependent introns 英文参考文献.doc

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Violating the splicing rules TG dinucleotides function as alternative 3 splice sites in U2-dependent introns 英文参考文献

Open Access Re rch 2007SzafranskietVoal.lumesea8, Issue 8, Article R154 Violating the splicing rules: TG dinucleotides function as alternative 3 splice sites in U2-dependent introns ¤ ¤ Karol Szafranski *, Stefanie Schindler *, Stefan Taudien*, Michael Hiller?, Klaus Huse*, Niels Jahn*, Stefan Schreiber?, Rolf Backofen? and Matthias Platzer* Addresses: *Genome Analysis, Leibniz Institute for Age Research - Fritz Lipmann Institute, Beutenbergstr., 07745 Jena, Germany. ?Institute of Computer Science, Bioinformatics Group, Albert-Ludwigs-University Freiburg, Georges-Koehler-Allee, 79110 Freiburg, Germany. ?Institute of Clinical Molecular Biology, Christian Albrechts University Kiel, Schittenhelmstr., 24105 Kiel, Germany. ¤ These authors contributed equally to this work. Correspondence: Karol Szafranski. Email: szafrans@fli-leibniz.de Published: 1 August 2007 Received: 8 March 2007 Revised: 14 June 2007 Accepted: 1 August 2007 Genome Biology 2007, 8:R154 (doi:10.1186/gb-2007-8-8-r154) The electronic version of this article is the complete one and can be found online at /2007/8/8/R154 ? 2007 Szafranski et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cite. TGp3TGalternativedinucleotspliceides fusitesnctioning as alternative 3 splice sites were identified and experimentally verified in 36 human genes./p Abstract Background: Despite some degeneracy of sequence signals that govern splicing of eukaryotic pre- mRNAs, it is an accepted rule that U2-dependent introns exhibit the 3 terminal dinucleotide AG. Intrigued by anecdotal evidence for functional non-AG 3 splice sites, we carried out a human genome-wide screen. Results: We identified TG dinucleotides functioning as alternative 3 splice sites in 36 human genes. The