Vasopressin impairs brain, heart and kidney perfusion an experimental study in pigs after transient myocardial ischemia 英文参考文献.docVIP

Available online /content/12/1/R20 Research Open Access Vol 12 No 1 Vasopressin impairs brain, heart and kidney perfusion: an experimental study in pigs after transient myocardial ischemia Stig Müller1, Ole-Jakob How1, Stig Eggen Hermansen1,2, Thor Allan Stenberg1, Georg Sager3 and Truls Myrmel1,2 1Laboratory of Surgical Research, Institute of Clinical Medicine, University of Troms?, N-9037 Troms?, Norway 2Department of Cardiothoracic and Vascular Surgery, University Hospital North Norway, Norway 3Department of Pharmacology, Institute of Medical Biology, University of Troms? N-9037 Troms?, Norway Corresponding author: Ole-Jakob How, olejak@fagmed.uit.no Received: 11 Nov 2007 Revisions requested: 10 Dec 2007 Revisions received: 6 Feb 2008 Accepted: 21 Feb 2008 Published: 21 Feb 2008 Critical Care 2008, 12:R20 (doi:10.1186/cc6794) This article is online at: /content/12/1/R20 ? 2008 Müller et al.; licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Introduction Arginine vasopressin (AVP) is increasingly used to restore mean arterial pressure (MAP) in low-pressure shock states unresponsive to conventional inotropes. This is potentially deleterious since AVP is also known to reduce cardiac output by increasing vascular resistance. The effects of AVP on blood flow to vital organs and cardiac performance in a circulation altered by cardiac ischemia are still not sufficiently clarified. We hypothesised that restoring MAP by low dose, therapeutic level AVP would reduce vital organ blood flow in a setting of experimental acute left ventricular dysfunction. dose therapeutic level of AVP (0.005 U/kg/min) was used to restore MAP to pre-ischemic values (93 ± 4 mmHg). Results AVP further impaired systemic