Variation in the PaO2FiO2 ratio with FiO2 mathematical and experimental description, and clinical relevance 英文参考文献.docVIP
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Variation in the PaO2FiO2 ratio with FiO2 mathematical and experimental description, and clinical relevance 英文参考文献
Available online /content/11/6/R118
Research
Open Access
Vol 11 No 6
Variation in the PaO /FiO ratio with FiO2: mathematical and
2
2
experimental description, and clinical relevance
Dan S Karbing1, S?ren Kj?rgaard2, Bram W Smith1, Kurt Espersen3, Charlotte Aller?d1,2,
Steen Andreassen1 and Stephen E Rees1
1Center for Model-based Medical Decision Support, Department of Health Science and Technology, Aalborg University, Fredrik Bajers Vej 7, E4-215,
DK-9220 Aalborg East, Denmark
2Anaesthesia and Intensive Care, Region North Jutland, Aalborg Hospital, Aarhus University, DK-9000 Aalborg, Denmark
3Department of Intensive Care, Rigshospitalet, University of Copenhagen, DK-2100 Copenhagen East, Denmark
Corresponding author: Dan S Karbing, dank@hst.aau.dk
Received: 2 Aug 2007 Revisions requested: 8 Sep 2007 Revisions received: 2 Oct 2007 Accepted: 7 Nov 2007 Published: 7 Nov 2007
Critical Care 2007, 11:R118 (doi:10.1186/cc6174)
This article is online at: /content/11/6/R118
? 2007 Karbing et al., licensee BioMed Central Ltd.
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/
2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Introduction Previous studies have shown through theoretical
analyses that the ratio of the partial pressure of oxygen in arterial
ventilation/perfusion model. These models and patient data
were used to investigate the variation in the PaO /FiO ratio with
2
2
blood (PaO2) to the inspired oxygen fraction (FiO ) varies with
FiO , and to quantify how many patients changed disease
2
2
the FiO level. The aim of the present study was to evaluate the
classification due to variation in the PaO /FiO ratio. An F test
2
2
2
relevance of this variation both theoretically and experimentally
using mathematical model simulations, comparing these ratio
simulations with Pa
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