Variations in abundance genome-wide responses to genetic variation and vice versa 英文参考文献.docVIP

/2002/3/10/reviews/1029.1 Minireview Variations in abundance: genome-wide responses to genetic variation… and vice versa Bruce A Hamilton Address: Department of Medicine (Division of Genetics), Department of Cellular and Molecular Medicine, and Rebecca and John Moores UCSD Cancer Center, University of California San Diego School of Medicine, La Jolla, CA 92093-0644, USA. E-mail: bah@ Published: 19 September 2002 GenomeBiology 2002, 3(10):reviews1029.1–1029.3 The electronic version of this article is the complete one and can be found online at /2002/3/10/reviews/1029 ? BioMed Central Ltd (Print ISSN 1465-6906; Online ISSN 1465-6914) Abstract How do naturally occurring polymorphisms in DNA sequence relate to variation in gene expression? Recent work to map genetic sources of expression variation has shown a surprising balance between cis and trans effects. Other work suggests some chromosomal clustering of genes by expression pattern. A synthesis of approaches may provide new insight in to adaptive mechanisms in evolution and the population basis of complex traits. Interpreting the functional significance of genetic polymor- phisms in natural populations poses a major challenge. Here I review recent work in yeast, flies, mice and primates that examines the influences of naturally occurring sequence variation, chromosomal order and speciation on genome- wide expression profiles of both RNA and protein. A syn- thetic view from these experiments would suggest that gene expression is not randomly distributed along chromosomes, that variations in mRNA and protein expression within a single species result from a surprising balance between poly- morphisms acting in cis and polymorphisms acting in trans to the regulated gene, and consequently that relatively few adaptive changes could have major impacts in remodeling gene expression patterns over the course of evolution. expression profiles between individual