Variation at APOE and STH loci and Alzheimers disease 英文参考文献.docVIP

Behavioral and Brain Functions BioMedCentral Research Open Access Variation at APOE and STH loci and Alzheimers disease Lingjun Zuo1,2, Christopher H van Dyck3, Xingguang Luo1,2, Henry R Kranzler4, Bao-zhu Yang1,2 and Joel Gelernter*1,2 Address: 1Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA, 2VA Connecticut Healthcare System, West Haven Campus, CT, USA, 3Alzheimers Disease Research Unit and Cognitive Disorders Clinic, Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA and 4Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT, USA Email: Lingjun Zuo - Lingjun.Zuo@; Christopher H van Dyck - christopher.vandyck@; Xingguang Luo - Xingguang.Luo@; Henry R Kranzler - kranzler@; Bao-zhu Yang - Bao-zhu.yang@; Joel Gelernter* - Joel.Gelernter@ * Corresponding author Published: 07 April 2006 Received: 15 March 2006 Accepted: 07 April 2006 Behavioral and Brain Functions 2006, 2:13 doi:10.1186/1744-9081-2-13 This article is available from: /content/2/1/13 ? 2006 Zuo et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Abstract Background: The apolipoprotein E (APOE) and tau proteins play important roles in the pathological development of Alzheimers disease (AD). Many studies have shown an association between the APOE gene and AD. Association between AD and the newly discovered saitohin (STH) gene, nested within the intron of the tau gene, has been reported. The present study aimed to elucidate the association between APOE and AD, and between STH and AD in our sample. Methods: The functional polymorphisms, rs429358 and rs7412, in the APOE gene (which together define the ε2, ε3, an