Variable antibiotic susceptibility patterns among Streptomyces species causing actinomycetoma in man and animals 英文参考文献.docVIP
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Variable antibiotic susceptibility patterns among Streptomyces species causing actinomycetoma in man and animals 英文参考文献
HamidAnnalsofClinicalMicrobiologyandAntimicrobials2011,10:24
/content/10/1/24
RESEARCH
OpenAccess
Variableantibioticsusceptibilitypatternsamong
Streptomycesspeciescausingactinomycetoma
inmanandanimals
MohamedEHamid
Abstract
Background:Drugtherapyisrecommendedinconjunctionwithsurgeryintreatmentofactinomycetoma.The
specificprescriptiondependsonthetypeofbacteria(actinomycetoma)orfungi(eumycetoma)causingthedisease
andtheirinvitroantimicrobialsusceptibility.
Objectives:ToinvestigatetheantimicrobialsusceptibilityamongisolatesofStreptomycesspp.isolatedfromcases
ofactinomycetomainmanandanimalsinSudan.
Methods:Streptomycesstrains(n=18)isolatedfromcasesofactinomycetomaweretestedinvitroagainst
15commonlyprescribedantibacterialagentsusingMICagardilutionmethodasperstandardguidelines.
Results:Streptomycesstrainsisolatedfromactinomycetomafallintovariousphenotypicgroups.Allofthestrains
wereinhibitedbynovobiocin(8μg/mL),gentamycin(8,32μg/mL)anddoxycycline(32μg/mL).Fusidicacid
(64μg/mL)inhibited94.4%ofthestrains;bacitracin,streptomycin,cephaloridine,clindamycin,ampicillin,rifampicin
andtetracycline(64μg/mL)inhibitedbetween61.1and77.8%ofthestrains.Allstrainswerefoundresistantto
amphotericinB(64μg/mL),penicillin(20μg/mL)andsulphamethoxazole(64μg/mL).
Conclusions:SaprophyticStreptomycesspp.causeactinomycetomainmanandanimalbelongtoseparate
phenotypesandhaveawiderangeofsusceptibilitypatternstoantimicrobialagents,whichposealotof
difficultiesinselectingeffectiveinvivotreatmentforactinomycetoma.
Keywords:Antibioticsusceptibility,Streptomyces,Actinomycetoma,Sudan
Background
grainsrepresentaggregatesofbacterialfilamentsorfun-
Actinomycetoma is a slowly progressive, destructive galhyphae.Thesalientfeaturesofthegrainsmayassist
infectionofthecutaneousandsubcutaneoustissues,fas- intheclinicaldiagnosis:eumycetomasduetoMadurella
cia, and bones, caused by fungi (eumycetoma) or by spp. typically produce black grains; actinomycetomas
aerobicactinomycetebacteria(actinomycetomaoracti- never
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