Validation of a specific measure to assess health-related quality of life in patients with schizophrenia and bipolar disorder the Tolerability and quality of life (TOOL) questionnaire 英文参考文献.docVIP

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Validation of a specific measure to assess health-related quality of life in patients with schizophrenia and bipolar disorder the Tolerability and quality of life (TOOL) questionnaire 英文参考文献.doc

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Validation of a specific measure to assess health-related quality of life in patients with schizophrenia and bipolar disorder the Tolerability and quality of life (TOOL) questionnaire 英文参考文献

Montejoetal.AnnalsofGeneralPsychiatry2011,10:6 /content/10/1/6 PRIMARY RESEARCH OpenAccess Validationofaspecificmeasuretoassesshealth- relatedqualityoflifeinpatientswithschizophrenia andbipolardisorder:the‘Tolerabilityandqualityof life’(TOOL)questionnaire AngelLMontejo1,JavierCorreasLauffer2,JesúsCuervo3,PabloRebollo3,LuisCordero4,TeresaDiez5, JorgeMaurino5* Abstract Background:Perceptionofqualityoflifemaydifferdependingontheperspective.Theaimofthestudywasto assessthepsychometricpropertiesoftheSpanishversionofthe‘TOlerabilityandqualityOfLife’(TOOL) questionnaire,aspecificself-ratedinstrumenttoevaluatetheimpactofsideeffectsofantipsychoticdrugsonhealth- relatedqualityoflife(HRQoL).Thequestionnaireconsistsofeightitemsansweredonafour-pointLikertscale. Methods:Apsychometricstudywasconductedwithclinicallystableoutpatientswithschizophreniaandbipolar disorderunderantipsychotictreatment.Thetranslationandculturaladaptationofthequestionnairewasperformed accordingtointernationalstandards.InternalconsistencyusingtheCronbachacoefficientandtest-retestreliability usingtheintraclasscorrelationcoefficient(ICC)wasusedtoassessthereliabilityoftheinstrument.Patients completedgenericandspecificmeasuresofqualityoflifeandclinicalseverity. Results:Atotalof238patientswereanalysed,withameanageof42years(SD10.9).Themeancompletiontime was4.9min(SD4.4).Internalconsistencyandintraclasscorrelationcoefficientwereadequate(Cronbacha=0.757 andICC=0.90).Factorialanalysisshowedaunidimensionalstructure(asingleeigenvalue1,accountingfor39.1% ofvariance).SignificantSpearman’srankcorrelationsbetweentheTOOLandbothgenericandspecificmeasures werefound.ThequestionnairewasabletodiscriminateamongtheClinicalGlobalImpression-Severityscores (Mann-WhitneyUtest,P0.001). Conclusions:TheTOOLquestionnaireshowsappropriatefeasibility,reliability,anddiscriminativeperformanceasa patient-reportedoutcome.TOOLconstitutesavaluableadditiontomeasuretheimpactofadverseeventsof antipsychoticdrugsfromthepatientperspective. Background