Variation of Ursolic Acid Content in Eight Ocimum Species from Northeastern Brazil 英文参考文献.docVIP

Molecules 2008, 13, 2482-2487; DOI: 10.3390/moleculeOPEN ACCESS molecules ISSN 1420-3049 /molecules Communication Variation of Ursolic Acid Content in Eight Ocimum Species from Northeastern Brazil M. Goretti V. Silva1,*, ícaro G. P. Vieira 2,3, Francisca N. P. Mendes 3, Irineu. L. Albuquerque 4 , Rogério N. dos Santos 1 , Fábio O. Silva 1 and Selene M. Morais 2 1 Departamento de Química Analítica e Fisico-Química - Departamento de Química Organica e Inorganica, Universidade Federal do Ceará, 60.455-970, Fortaleza, CE, Brazil 2 Laboratório de Química de Produtos Naturais, Universidade Estadual do Ceará, Campus do Itaperí, CEP 60.740-000, Fortaleza, CE, Brazil 3 Parque de Desenvolvimento Tecnológico (PADETEC), 60455-970, Fortaleza, CE, Brazil 4 Universidade de Fortaleza, 60811-905, Fortaleza, CE, Brazil * Author to whom correspondence should be addressed; E-mail: mgvsilva@ufc.br. Received: 27 June 2008; in revised form: 16 September 2008 / Accepted: 16 September 2008 / Published: 14 October 2008 Abstract: Ursolic acid is a very important compound due to its biological potential as an anti-inflammatory, trypanocidal, antirheumatic, antiviral, antioxidant and antitumoral agent. This study presents the HPLC analysis of ursolic acid (UA) content in eight different Ocimum species: O. americanum L., O. basilicum L, O. basilicum var purpurascens Benth, O. basilicum var. minimum L, O. gratissimum L, O. micranthum Willd, O. selloi Benth. and O. tenuiflorum L. grown in Northeastern Brazil. In these Ocimum species, UA was detected in different yields, with O. tenuiflorum showing the highest content (2.02%). This yield is very significant when compared with other sources of UA. Keywords: Labiatae; Ursolic acid; Ocimum; HPLC  Molecules 2008, 13 2483 Introduction Ursolic acid (3β-hydroxy-urs-12-en-28-oic acid) is an ursane type triterpene (Figure 1) found in all parts of plants