光学断层相干扫描-第三军医大学学报.doc

原发性慢性闭角型青光眼视盘损害可行性评估与光学断层相干扫描和视野检测的相关性研究 李海军1 乐莉1 王原1 谢琳1. 1第三军医大学大坪医院野战外科研究所眼科专科医院，重庆市重点实验室，地址：重庆市渝中区长江支路10号400042 摘要： 目的：本研究对重庆地区原发性慢性闭角型青光眼病人进行视盘损害可行性评估（Disc Damage Likelihood Scale DDLS），并结合光学断层相干扫描议（optical coherence tomography， OCT）和Humphrey视野计检测结果进行相关性分析研究。 方法：38例（73眼）原发性慢性闭角型青光眼患者，其中大视盘17眼(占23.3%) ,中等大小视盘41眼(占56.2% ) ,小视盘15眼(占20.6% )，在裂隙灯下通过双面Volk 90D前置镜对视盘直径测量及其盘沿最窄处宽度测量，按DDLS分级标准进行评分；并应用OCT测视盘参数，及Humphrey视野计24－2程序（Swedish Interactive Threshold Algorithm standard，SITA 24-2）检查视野变化。分析DDLS评分值、OCT视盘检测参数和视野值的相关性。 结果：DDLS 评分值与OCT检测视盘参数，除颞侧与鼻上方区域神经纤维厚度不相关外（r=0.039, p=0.8108, r=0.40, p=0.0101），其余区域明显相关(r＝0.44 to －0.878, Ps＜0.005)(r=－0.878, p＜0.0001)(r =－0.593, p＜0.0001, r =0.60, p＜0.0001)r =－0.02，p＝0.058），颞下方盘沿面积呈中度相关（r =－0.53，p＜0.0001关键词视野青光眼相关性The relationship between the Disc Damage Likelihood Scale (DDLS), visual field and optical coherence tomography (OCT) parameters for primary chronic angle-closure glaucoma optic neuropathy Li Haijun1，Yue Li1, Wang Yuan1, Xie Lin1. From the department of ophthalmology, Daping Hospital, the third military medical university. Chongqing Key Laboratory of Ophthalmology，Chongqing 400042, China Abstract Purpose-To evaluate relationships between the Disc Damage Likelihood Scale (DDLS), global and regional functional loss in visual field (VF) testing, and optical coherence tomography (OCT) parameters for primary chronic angle–closure glaucoma in China. Methods-Thirty-eight primary chronic angle-closure glaucoma participants were enrolled to assess the DDLS score by dilated ophthalmoscopy with a 90-diopters (D) len and test with OCT and Swedish Interactive Threshold Algorithm standard 24-2 VF tests with the HFA. The relationships among clinical DDLS score, OCT parameters, and VF values were analyzed by correlation coefficients and linear regression analysis. Results- The DDLS showed significant correlation with all of sector OCT parameters except of temporal and superonasal areas, (respectively r＝－0.44 to －0.878, all Ps＜0.005; r=－